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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT06438887
Other study ID # Bio-REB 4641
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date May 15, 2024
Est. completion date August 30, 2025

Study information

Verified date May 2024
Source University of Regina
Contact Darren Candow
Phone 3062090280
Email Darren.Candow@uregina.ca
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Creatine supplementation improves measures of muscle accretion and performance compared to placebo during a resistance training program. However, the optimal creatine supplementation protocol for maximizing these improvements is unknown.


Description:

Creatine is a naturally occurring nitrogen containing compound endogenously produced in the body through reactions involving the amino acids arginine, glycine and methionine. Alternatively, creatine can be consumed in the diet (primarily from red meat and seafood) or through commercially manufactured creatine. It has been proposed that the strategic ingestion of creatine supplementation may be an important factor to consider during a resistance training program to increase muscle growth and performance. There is evidence that creatine supplementation only on training days has greater muscle benefits compared to placebo in healthy older adults. However, the effects of creatine on training days (compared to creatine on non-training days or placebo) in healthy young adults is unknown. Further, pre- and post-exercise creatine supplementation appears to produce similar muscle benefits (compared to placebo) in healthy older adults. It remains to be determined whether the timing of creatine ingestion (immediately before vs. immediately following training sessions) influences the physiological adaptations from resistance training compared to placebo in young healthy adults. It is also unknown whether differences exist in supplementing with creatine immediately before, during or immediately following resistance training sessions in young healthy adults.


Recruitment information / eligibility

Status Recruiting
Enrollment 52
Est. completion date August 30, 2025
Est. primary completion date December 30, 2024
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 39 Years
Eligibility Inclusion Criteria: - Physically active (performing structured resistance training > 2x/week for = 4 weeks) - Males and females (age 18-39) Exclusion Criteria: - Pregnant or nursing - Have consumed creatine monohydrate within 30 days prior to the start of the study - Pre-existing allergies to the placebo

Study Design


Related Conditions & MeSH terms


Intervention

Dietary Supplement:
Placebo
Corn-Starch Maltodextrin
Creatine monohydrate
Creatine

Locations

Country Name City State
Canada University of Regina Regina Saskatchewan
Canada University of Regina Regina

Sponsors (1)

Lead Sponsor Collaborator
University of Regina

Country where clinical trial is conducted

Canada, 

Outcome

Type Measure Description Time frame Safety issue
Primary Body Composition Whole-body lean mass (kg) using bioelectrical impedance analysis baseline, week 16
Primary Muscle Hypertrophy Muscle thickness of the biceps, triceps, quadriceps, hamstrings and calf muscle using B-mode ultrasound (cm) baseline, week 16
Primary Strength 1-repetition maximum leg press and chest press (kg) baseline, week 16
Primary Endurance Repetitions to fatigue for leg press and chest press (total number) baseline, week 16
Primary Power Medicine ball throw (cm) baseline, week 16
Primary Hydration Total body water (kg) using bioelectrical impedance analysis baseline, week 16
Primary Power Vertical jump (watts) baseline, weekn 16
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