Strategic Ingestion of Creatine Supplementation and Resistance Training in Trained Young Adults

Strength Clinical Trial

Official title:

Strategic Ingestion of Creatine Supplementation and Resistance Training in Trained Young Adults

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06438887
• Other study ID #: Bio-REB 4641
• Status: Recruiting
• Phase: N/A
• Start date: May 15, 2024
• Est. completion date: August 30, 2025

Study information

• Verified date: May 2024
• Source: University of Regina
• Contact: Darren Candow
• Phone: 3062090280
• Email: Darren.Candow[@]uregina.ca
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Creatine supplementation improves measures of muscle accretion and performance compared to placebo during a resistance training program. However, the optimal creatine supplementation protocol for maximizing these improvements is unknown.

Description:

Creatine is a naturally occurring nitrogen containing compound endogenously produced in the body through reactions involving the amino acids arginine, glycine and methionine. Alternatively, creatine can be consumed in the diet (primarily from red meat and seafood) or through commercially manufactured creatine. It has been proposed that the strategic ingestion of creatine supplementation may be an important factor to consider during a resistance training program to increase muscle growth and performance. There is evidence that creatine supplementation only on training days has greater muscle benefits compared to placebo in healthy older adults. However, the effects of creatine on training days (compared to creatine on non-training days or placebo) in healthy young adults is unknown. Further, pre- and post-exercise creatine supplementation appears to produce similar muscle benefits (compared to placebo) in healthy older adults. It remains to be determined whether the timing of creatine ingestion (immediately before vs. immediately following training sessions) influences the physiological adaptations from resistance training compared to placebo in young healthy adults. It is also unknown whether differences exist in supplementing with creatine immediately before, during or immediately following resistance training sessions in young healthy adults.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 52
• Est. completion date: August 30, 2025
• Est. primary completion date: December 30, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 39 Years

Eligibility

Inclusion Criteria:

• Physically active (performing structured resistance training > 2x/week for = 4 weeks)

• Males and females (age 18-39)

Exclusion Criteria:

• Pregnant or nursing

• Have consumed creatine monohydrate within 30 days prior to the start of the study

• Pre-existing allergies to the placebo

Related Conditions & MeSH terms

• Muscle
• Strength

Intervention

Dietary Supplement:
• Placebo
Corn-Starch Maltodextrin
• Creatine monohydrate
Creatine

Locations

Country	Name	City	State
Canada	University of Regina	Regina	Saskatchewan
Canada	University of Regina	Regina

Sponsors (1)

Lead Sponsor	Collaborator
University of Regina

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Body Composition	Whole-body lean mass (kg) using bioelectrical impedance analysis	baseline, week 16
Primary	Muscle Hypertrophy	Muscle thickness of the biceps, triceps, quadriceps, hamstrings and calf muscle using B-mode ultrasound (cm)	baseline, week 16
Primary	Strength	1-repetition maximum leg press and chest press (kg)	baseline, week 16
Primary	Endurance	Repetitions to fatigue for leg press and chest press (total number)	baseline, week 16
Primary	Power	Medicine ball throw (cm)	baseline, week 16
Primary	Hydration	Total body water (kg) using bioelectrical impedance analysis	baseline, week 16
Primary	Power	Vertical jump (watts)	baseline, weekn 16