Duodenal Ulcer Clinical Trial
Official title:
A Study to Investigate the Preventive Effect of AG-1749 Against the Recurrence of Gastric And Duodenal Ulcers During Long-Term Treatment With Low Dose Aspirin.
The purpose of this study is to determine whether lansoprazole, once daily (QD), compared to gefarnate, twice daily (BID), is effective in preventing the recurrence of gastric and duodenal ulcers in patients receiving long term treatment with low dosage aspirin.
In Japan, low-dose aspirin is one of the commonly prescribed drugs for inhibiting thrombosis
and thrombus formation after angina, myocardial infarction, ischemic cerebrovascular
disease, coronary artery by-pass surgery and percutaneous transluminal coronary angioplasty
in patients. While low-dose aspirin is effective in these cases, its use sometimes causes
gastric and duodenal ulcers which can lead to gastrointestinal bleeding, and in worse cases
may lead to death.
The purpose of this study is to assess the efficacy of lansoprazole versus gefarnate in
patients with a history of gastric or duodenal ulcers receiving daily low dose aspirin
therapy.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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