Uterus Transplantation Procedure From a Live Donor

Sterility, Female Clinical Trial

Official title: Feasibility Study of Uterus Transplantation Procedure From a Live Donor Obtaining the Graft by Laparoscopy

Status Recruiting

Clinical Trial Summary

Absolut uterine factor, meaning the absence of uterus, represents a cause for sterility without the possibility of a present treatment. The uterine factor affects millions of women and may be due to congenital problems, such as the Muller anomalies (Mayer Rockitansky Syndrome) or acquired by previous hysterectomy or intrauterine adhesions (Asherman's Syndrome). The uterine transplant would represent the only possibility for patients with an absolute uterine factor to achieve both genetic and gestational maternity.

Clinical Trial Description

To obtain by laparoscopy a viable uterus for transplantation from a living donor is feasible. The laparoscopic procedure increases safety and provides the benefits of minimally invasive surgery to the grafting technique already described by laparotomy. The objective of the present study is to develop a pilot program in the transplant of a living donor. We include 5 pairs of uterine donor-transplant recipients indicated for sterility by absolute uterine factor due to Mayer Rokitansky Syndrome. Patients will undergo surgery for this transplant and after 6 months of it with correct function of the graft, embryos will be transferred in order to achieve pregnancy. C-section will be performed for delivery. The attempt of two gestations (if there are sufficient cryopreserved embryos for a second gestation) and withdrawing the graft (hysterectomy) and, therefore, immunosuppression is agreed. ;

Related Conditions & MeSH terms

• Infertility
• Infertility, Female
• Rokitansky Kuster Hauser Syndrome
• Sterility, Female

• NCT number: NCT04314869
• Study type: Interventional
• Source: Hospital Clinic of Barcelona
• Contact: Mariona Rius, MD
• Phone: 932275400
• Email: marius@clinic.cat
• Status: Recruiting
• Phase: N/A
• Start date: May 23, 2020
• Completion date: December 2025