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Exogenous Ketone Esters for Refractory Status Epileptics — EKERSE  

Status Epilepticus Clinical Trial

Official title:
Efficacy of Exogenous Ketone Esters for Children With Refractory Convulsive Status Epileptics

Clinical Trial Summary

This study aims to investigate the efficacy of add-on exogenous ketone esters for the treatment of children with refractory generalized convulsive status epilepticus

Clinical Trial Description

Generalized convulsive status epilepticus (GCSE) is a common neurological emergency in children with significant morbidity and mortality. Benzodiazepines (Bzs) are the initial anti-seizure medications (ASMs) for children with GCSE, but nearly a third of cases are not controlled by (Bzs). Moreover, about 40% of cases not responding to BZs are not controlled by second-line ASMs. Ketogenic diet (KD) has been classically used for treating children with drug resistant epilepsy. Recently, KD has been used for refractory and super refractory status epilepticus. However, KD takes time to achieve ketosis and may be practically challenging in emergency situations and critically ill patients. Exogenous ketone esters (EKE) could be a more convenient and rapid way to achieve ketosis in acute settings. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05674552
Study type Interventional
Source Sohag University
Contact Elsayed M Abdelkreem, MD, PhD
Phone 01114232126
Email d.elsayedmohammed@med.sohag.edu.eg
Status Recruiting
Phase Phase 2/Phase 3
Start date January 10, 2023
Completion date July 1, 2024
View Details
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