Clinical Trials Logo

Clinical Trial Summary

Status epilepticus (SE) is a common life-threatening neurological emergency in which prolonged or multiple closely spaced seizures can result in long-term impairments. SE remains associated with considerable mortality and morbidity, with little progress over the last three decades. The proportion of patients who die in the hospital is about 20% overall and 40% in patients with refractory SE. Morbidity is more difficult to evaluate, as adverse effects of SE are often difficult to differentiate from those attributed to the cause of SE. Our experience suggests that nearly 50% of patients may experience long-term functional impairments. The precise description of the consequences of these functional impairments and their impact on quality of life after SE requiring intensive care management has been little studied. Indeed, if cognitive, physical and mental impairments are now identified in the populations of patients who required intensive care under the term post-resuscitation syndrome (PICS), neuronal lesions consecutive to the SE itself or to its cause could be responsible for these different functional alterations. Thus, the following have been described: (i) cognitive disorders in the areas of attention, executive functions and verbal fluency, visual and working memory disorders, but also spatio-temporal disorders; (ii) physical disorders such as the so-called post-resuscitation polyneuromyopathy; and (iii) mental disorders such as anxiety disorders, depressive states or those related to post-traumatic stress. Assessment and characterization of patient-reported outcomes is essential to complement the holistic assessment of clinically relevant outcomes from the patient's perspective. Here, we propose the development of a cross-sectional collection of PROs of the different constituents of PICs and HR-QOLs, and associated with functional patient outcomes, in those who required ICU management for status epilepticus.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05491590
Study type Observational
Source Versailles Hospital
Contact Gwenaelle JACQ, RN,MSc,PhDc
Phone 0139638356
Email gjacq@ght78sud.fr
Status Recruiting
Phase
Start date November 9, 2022
Completion date March 1, 2024

See also
  Status Clinical Trial Phase
Not yet recruiting NCT04361032 - Assessment of Efficacy and Safety of Tocilizumab Compared to DefeROxamine, Associated With Standards Treatments in COVID-19 (+) Patients Hospitalized In Intensive Care in Tunisia Phase 3
Completed NCT03520023 - Critical Care and Palliative Care Medicine Together in the ICU N/A
Completed NCT01169571 - Study to Evaluate Hemodynamic Effect of Different Loading Doses of Precedex in Post-surgical Intensive Care Unit (ICU) Patients N/A
Completed NCT01168128 - PERFormance Enhancement of the Canadian Nutrition Guidelines by a Tailored Implementation Strategy: The PERFECTIS Study N/A
Recruiting NCT05029167 - REstrictive Versus LIberal Oxygen Strategy and Its Effect on Pulmonary Hypertension After Out-of-hospital Cardiac Arrest (RELIEPH-study) N/A
Recruiting NCT06176807 - Prediction of Acute Kidney Injury in Patients With Sepsis Using Venous Excess Ultrasound Score
Not yet recruiting NCT05367011 - Therapeutic Monitoring of Antibiotics in Intensive Care Patients: a Cohort Study PopTDM-ICU
Recruiting NCT05056090 - Effect of Prone Positioning on Mortality in Patients With Mild to Moderate Acute Respiratory Distress Syndrome. N/A
Completed NCT04503135 - Catheter Associated Asymptomatic Thrombosis in Intensive Care Unit
Completed NCT03983044 - Comparison of Two Methods for Assessing Cough Capacity in Intensive Care Unit After Cardiac Surgery
Completed NCT05573659 - Capillary Refill Time Calculated With a Video-assisted Method Has a Better Reproducibility Than Visual Method in Critically Ill Patients N/A
Completed NCT06032169 - Ankle Measurements of Arterial Pressure: Semi-recumbent or Horizontal Position.
Completed NCT04199273 - Assessment of Human Diaphragm Strength by Magnetic and Electric Stimulation After Ultrasonography Phrenic Nerve Tracking N/A
Recruiting NCT04353804 - Returning to Everyday Tasks Utilizing Rehabilitation Networks-III (RETURN-III) Phase 2
Completed NCT03681626 - Does Tracheal Suction During Extubation in Intensive Care Unit Decrease Functional Residual Capacity N/A
Recruiting NCT04094428 - Burden, Mortality and Supply Costs in Intensive Care Unit Patients
Completed NCT04014920 - Non-invasive Ventilation Following Extubation (Prophylactic) to Prevent Extubation Failure in Critically Obese Patients N/A
Completed NCT05131633 - Regional Anaesthesia in Intensive Care Unit
Completed NCT06239987 - The Effect of Care-oriented Practical Training on Nurses' Intensive and Critical Care Competency and HAIs Indicators N/A
Completed NCT06121024 - Long-term Outcomes of Post-intubation Tracheal Stenosis; 7-year Follow-up