Infertility Clinical Trial
Official title:
Dietary Energy Requirements in Physically Active Men and Women, Objective 4B: Effects of Gynecological Age on LH Sensitivity to Energy Availability
The purpose of this experiment is to investigate whether the dependence of luteinizing hormone pulsatility on energy availability declines during adolescence.
The incidence of menstrual disorders declines during adolescence. This has long been
attributed to the gradual "maturation" of the hypothalamic-pituitary-ovarian axis, but the
mechanism of this "maturation" is not known. Ovarian function critically depends on the
pulsatile secretion of gonadotropin-releasing hormone (GnRH) by the hypothalamus and on the
consequent and more readily assessed pulsatility of luteinizing hormone (LH) secretion by
the pituitary. LH pulsatility has been shown to depend on energy availability, operationally
defined as dietary energy intake minus exercise energy expenditure. The effects of energy
availability on LH pulsatility are thought to be mediated by certain metabolic substrates
and hormones.
Comparison: By manipulating diet and exercise regimens, contrasting energy availability
treatments of 10 and 45 kilocalories per kilogram of fat-free mass per day are being
administered to adolescents with 5-8 years of gynecological age and to adults with 14-18
years of gynecological age for five days in the early follicular phase of separate menstrual
cycles. Effects of low energy availability on LH pulsatility and on selected metabolic
substrates and hormones are being measured.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Prevention
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