Clinical Trials Logo
  1. Home
  2. Staphylococcus Aureus
  3. NCT03220386

Methicillin-sensitive and Methicillin-resistant Staphylococcus Aureus (MSSA/MRSA) - Point-of-care-testing (POCT) in Clinical Decision Making — EPICS-6  

Staphylococcus Aureus Clinical Trial

Official title:
Methicillin-sensitive and Methicillin-resistant Staphylococcus Aureus (MSSA/MRSA) - Point-of-care-testing (POCT) in Clinical Decision Making

Clinical Trial Summary

The study EPICS-6 consists of three study phases. Emergency Department patients are screened for nasal and pharyngeal colonisation with Methicillin sensitive and Methicillin resistant Staphylococcus aureus (MSSA/MRSA) using a point-of-care (POC)-PCR-testing method (cobas®LIAT®-System, Roche Molecular Systems Inc.) The first aim of this study is to describe the prevalence of MSSA/MRSA-colonisation in a routine cohort of Emergency Department patients. The second aim is to determine the impact of POC-guided decolonisation as compared to conventional laboratory testing on in-hospital infection rates with MSSA/MRSA in a pre-post-comparison study.

Clinical Trial Description

The study EPICS-6 consists of three study phases. In phase one the novel POC-PCR-testing method for MSSA/MRSA-proof (cobas®LIAT®-System, Roche Molecular Systems Inc.) is technically established and integrated in Emergency Department procedures. After evaluation of processes and sample handling the second phase of this study assesses the prevalence of positive MSSA/MRSA-POC-testing in the general ED-population and in different risk groups. Based on the results of the previous study phases, the final phase comprises an interventional pre-post-comparison study. The interventional study assesses the impact of POC-result guided early decolonisation of MSSA/MRSA-colonized patients on in-hospital infection rates with MSSA/MRSA. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03220386
Study type Interventional
Source Charite University, Berlin, Germany
Contact Martin Möckel, PhD, MD
Phone +49 30 450 553 472
Email martin.moeckel@charite.de
Status Recruiting
Phase N/A
Start date May 1, 2017
Completion date August 1, 2018
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT05073926 - Rifampicin Resistance in S. Aureus During and After Treatment for Latent Tuberculosis
Completed NCT01212120 - The Foot in Your Nose Study: Links Between Nasal Staphylococcus Aureus Colonies and Diabetic Foot Lesion Infections N/A
Completed NCT00801879 - Mupirocin Ointment to Eliminate Nasal Carriage of Staphylococcus Aureus in HIV Infection Phase 4
Terminated NCT03638947 - Reducing Perioperative S. Aureus Transmission N/A
Recruiting NCT05331885 - A Human Monoclonal Antibody Against Staphylococcus Aureus Alpha Toxin in Mechanically Ventilated Adult Subjects - 2 Phase 3
Recruiting NCT05094570 - Interleukin-4Ra Blockade by Dupilumab Decreases Staphylococcus Colonization and Increases Microbial Diversity in CRSwNP Phase 4
Not yet recruiting NCT05092464 - Exploratory Study to Evaluate the Application of NLAC Cream in Adults With Atopic Dermatitis N/A
Recruiting NCT05695196 - Feasibility and Safety Study of Parent-to-Child Nasal Microbiota Transplant Phase 1
Enrolling by invitation NCT04666532 - S. Aureus Translocation From Skin and Nose to Periprosthetic Tissues
Active, not recruiting NCT02572791 - Staph Household Intervention for Eradication (SHINE) Phase 4
Recruiting NCT04274348 - Staphylococcal Toxins in Atopic Dermatitis and Eczema Herpeticum N/A
Enrolling by invitation NCT05880069 - Clinical Outcomes in Patients With Infection by Resistant Microorganism
Completed NCT01011335 - Staphylococcus Aureus Toxoids Phase 1-2 Vaccine Trial Phase 1/Phase 2
Completed NCT03816956 - Adjunctive Therapy to Antibiotics in the Treatment of S. Aureus Ventilator-Associated Pneumonia With AR-301 Phase 3
Not yet recruiting NCT04884958 - A Study to Investigate the Transmission and Burden of PVL-MRSA in Households in Sri Lanka
Completed NCT01105767 - Methicillin-resistant Staphylococcus Aureus (MRSA) Skin and Soft Tissue Infection (SSTI) Prevention in Military Trainees N/A
Completed NCT00475930 - Chlorhexidine Impregnated Cloths to Prevent Skin and Soft Tissue Infections in Marine Officer Candidates N/A
Completed NCT00507247 - Daptomycin in the Treatment of Catheter-Related Staphylococcus Aureus Phase 2
Completed NCT03140423 - Mupirocin-Iodophor ICU Decolonization Swap Out Trial Phase 4
Not yet recruiting NCT03869593 - Role of the NLRP3 Inflammasome in Escherichia Coli and Staphylococcus Aureus Bacteria