Early Infectious Disease Consultations in Staphylococcus Aureus Bacteremia

Staphylococcus Aureus Bacteremia Clinical Trial

Official title: Early Infectious Disease Consultation for Better Outcomes From Staphylococcus Aureus Bacteremia

Status Recruiting

Clinical Trial Summary

The primary objective is to determine if early infectious disease (ID) consultation (defined as within 48 hours of a positive blood culture) will reduce mortality rates from Staphylococcus aureus bacteremia (SAB). This study will also determine if such consultations could reduce the duration of hospitalisation, recurrence and financial costs in patients with this infection.

Clinical Trial Description

Bacteremia is a serious manifestation of Staphylococcus aureus infection with an attributable mortality as high as 25% in MRSA bacteremia. More than a third of patients end up with complications such as endocarditis, osteomyelitis or pneumonia.

Overall the outcome of patients with respect to mortality or recurrence is better in patients who have an eradicable focus and have received an appropriate antibiotic dose and duration. Also complicated bacteremia is more common in patients with

• persistent bacteremia or fever

• prosthetic device

• new murmur

• skin findings of a systemic infection

Based on this evidence, an ID consultation could improve the outcomes of patients with SAB by

• Advising adequate antibiotic dosage and duration

• Sourcing out and counselling eradication of any focus of infection ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Health Services Research

Related Conditions & MeSH terms

• Bacteremia
• Communicable Diseases
• Infection
• Staphylococcus Aureus Bacteremia

• NCT number: NCT00622882
• Study type: Interventional
• Source: National University Hospital, Singapore
• Contact: Paul A Tambyah, MD
• Phone: (65)67724375
• Email: mdcpat@nus.edu.sg
• Status: Recruiting
• Phase: N/A
• Start date: October 2007
• Completion date: December 2015