Staphylococcus Aureus Clinical Trial
Official title:
The Natural History of Community-Associated Methicillin-Resistant Staphylococcus Aureus (CA-MRSA) Infections and an Evaluation of Decolonization Strategies
The purpose of this study is to determine the natural history of community-associated
Staphylococcus aureus infections in both adult and pediatric patients by monitoring the rate
of recurrent infections in those colonized with S. aureus.
In addition, this study will evaluate the efficiency of commonly prescribed decolonization
measures in patients presenting with S. aureus skin and soft tissue infections.
Infections with community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA)
range in severity from superficial skin abscesses to invasive soft tissue infections like
cellulitis and pyomyositis. There has been a large increase in the number of patients
presenting to our institution with CA-MRSA infections. Colonization with S. aureus (SA) may
be linked to the development of infection but data on this phenomenon are limited. The
recurrence rate for CA-MRSA soft tissue infections is unknown. A variety of decolonization
strategies have been used for infection prophylaxis with varying results, primarily in
patients undergoing hemodialysis or surgery. This study seeks to determine the recurrence
rate of soft tissue infections among patients with CA-MRSA infections and to determine a
reasonable and efficacious decolonization strategy to eradicate CA-MRSA from previously
infected patients.
The proposed methods for decolonization will be tested in a randomized controlled trial with
four intervention arms. The intervention arms are: (1) intensive education on prevention of
skin infections through improvements in personal hygiene (also serves as "control group"),
(2) application of mupirocin in the nasal mucosa alone, (3) a combination of nasal
application of mupirocin and chlorhexidine showers, and (4) a combination of nasal
application of mupirocin and bathing in dilute bleach water. The "control" group as well as
the three other arms will receive intensive hygiene education.
Decolonization with mupirocin ointment and chlorhexidine showers or dilute bleach baths in
combination are likely to be more successful than either the application of nasal mupirocin
ointment alone or hygiene measures alone. It is expected that these decolonization methods
will result in a 50% relative reduction in MRSA colonization at 6 months.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05073926 -
Rifampicin Resistance in S. Aureus During and After Treatment for Latent Tuberculosis
|
||
Completed |
NCT01212120 -
The Foot in Your Nose Study: Links Between Nasal Staphylococcus Aureus Colonies and Diabetic Foot Lesion Infections
|
N/A | |
Completed |
NCT00801879 -
Mupirocin Ointment to Eliminate Nasal Carriage of Staphylococcus Aureus in HIV Infection
|
Phase 4 | |
Terminated |
NCT03638947 -
Reducing Perioperative S. Aureus Transmission
|
N/A | |
Recruiting |
NCT05331885 -
A Human Monoclonal Antibody Against Staphylococcus Aureus Alpha Toxin in Mechanically Ventilated Adult Subjects - 2
|
Phase 3 | |
Recruiting |
NCT05094570 -
Interleukin-4Ra Blockade by Dupilumab Decreases Staphylococcus Colonization and Increases Microbial Diversity in CRSwNP
|
Phase 4 | |
Not yet recruiting |
NCT05092464 -
Exploratory Study to Evaluate the Application of NLAC Cream in Adults With Atopic Dermatitis
|
N/A | |
Recruiting |
NCT05695196 -
Feasibility and Safety Study of Parent-to-Child Nasal Microbiota Transplant
|
Phase 1 | |
Enrolling by invitation |
NCT04666532 -
S. Aureus Translocation From Skin and Nose to Periprosthetic Tissues
|
||
Active, not recruiting |
NCT02572791 -
Staph Household Intervention for Eradication (SHINE)
|
Phase 4 | |
Recruiting |
NCT04274348 -
Staphylococcal Toxins in Atopic Dermatitis and Eczema Herpeticum
|
N/A | |
Enrolling by invitation |
NCT05880069 -
Clinical Outcomes in Patients With Infection by Resistant Microorganism
|
||
Completed |
NCT01011335 -
Staphylococcus Aureus Toxoids Phase 1-2 Vaccine Trial
|
Phase 1/Phase 2 | |
Completed |
NCT03816956 -
Adjunctive Therapy to Antibiotics in the Treatment of S. Aureus Ventilator-Associated Pneumonia With AR-301
|
Phase 3 | |
Not yet recruiting |
NCT04884958 -
A Study to Investigate the Transmission and Burden of PVL-MRSA in Households in Sri Lanka
|
||
Completed |
NCT01105767 -
Methicillin-resistant Staphylococcus Aureus (MRSA) Skin and Soft Tissue Infection (SSTI) Prevention in Military Trainees
|
N/A | |
Completed |
NCT00475930 -
Chlorhexidine Impregnated Cloths to Prevent Skin and Soft Tissue Infections in Marine Officer Candidates
|
N/A | |
Completed |
NCT00507247 -
Daptomycin in the Treatment of Catheter-Related Staphylococcus Aureus
|
Phase 2 | |
Recruiting |
NCT03220386 -
Methicillin-sensitive and Methicillin-resistant Staphylococcus Aureus (MSSA/MRSA) - Point-of-care-testing (POCT) in Clinical Decision Making
|
N/A | |
Completed |
NCT03140423 -
Mupirocin-Iodophor ICU Decolonization Swap Out Trial
|
Phase 4 |