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Clinical Trial Summary

This phase I trial studies the sides effects and best dose of hydroxychloroquine when given together with trametinib in treating patients with pancreatic cancer that has spread to nearby tissue, lymph nodes or other places in the body and cannot be removed by surgery. Trametinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as hydroxychloroquine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving trametinib together with hydroxychloroquine may work better in treating patients with pancreatic cancer.


Clinical Trial Description

PRIMARY OBJECTIVES: I. To determine the recommended phase II dose of hydroxychloroquine in combination with trametinib as assessed by the occurrence of dose-limiting toxicities (DLTs). ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03825289
Study type Interventional
Source University of Utah
Contact Susan Sharry
Phone 801-585-3453
Email susan.sharry@hci.utah.edu
Status Recruiting
Phase Phase 1
Start date January 18, 2019
Completion date January 18, 2026

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