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Stage IV clinical trials

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NCT ID: NCT06114108 Recruiting - Clinical trials for Non-small Cell Lung Cancer (NSCLC)

Trial Comparing Systemic Therapy Alone and With Local Ablative Treatment for Stage IV NSCL Cancer Patients

salVage
Start date: December 21, 2023
Phase: N/A
Study type: Interventional

Unfortunately, most patients are already at a very advanced stage when they are diagnosed with lung cancer, i.e. the cancer has already spread outside the lungs forming metastases. The current standard of care therapy at this advanced stage of lung cancer includes systemic anti-cancer therapy such as chemotherapy, immunotherapy to boost the body's immune response, or targeted therapy that directly hinders tumor growth. In this study, the aim is to find out whether it is better if, after a good response to the standard therapy, the remains of main tumor and the metastases are additionally treated by surgery and/or radiation.

NCT ID: NCT04263090 Completed - Clinical trials for Non-small Cell Lung Cancer

Rigosertib Plus Nivolumab for KRAS+ NSCLC Patients Who Progressed on First-Line Treatment

Start date: June 29, 2020
Phase: Phase 1/Phase 2
Study type: Interventional

A Phase1/2a Study of Rigosertib plus Nivolumab in Stage IV Lung Adenocarcinoma Patients with KRAS Mutation who Progressed on First-Line Treatment

NCT ID: NCT03965468 Recruiting - Clinical trials for Non-small Cell Lung Cancer

Immunotherapy, Chemotherapy, Radiotherapy and Surgery for Synchronous Oligo-metastatic NSCLC

CHESS
Start date: November 19, 2019
Phase: Phase 2
Study type: Interventional

A multicentre single arm phase II trial assessing the efficacy of immunotherapy, chemotherapy plus stereotactic radiotherapy to metastases followed by definitive surgery or radiotherapy to the locoregional primary tumour, in patients with histologically-confirmed synchronous oligo-metastatic non-small cell lung cancer (NSCLC).

NCT ID: NCT03565120 Recruiting - Clinical trials for Carcinoma, Non-Small-Cell Lung

Aggressive Thoracic Radiotherapy for Stage Ⅳ Non Small Cell Lung Cancer

Start date: December 10, 2018
Phase: N/A
Study type: Interventional

This phase II trial studies the safety and efficacy of aggressive thoracic radiotherapy in treating patients with non-small cell lung cancer that has not progressed after the first line systemic therapy. In this trial, patients with stage Ⅳ non small cell lung cancer who did not progress after first line systemic therapy will receive the aggressive thoracic radiotherapy, and the safety and efficacy of aggressive thoracic radiotherapy will be evaluated. The primary end points of the study are overall survival (OS), the secondary end points are local control rate, local progression free survival(LPFS), PFS, and toxicity and quality of life(QOL).

NCT ID: NCT02374255 Completed - Colorectal Cancer Clinical Trials

Improving Goals of Care Discussion in Advanced Cancer Patients

Start date: March 15, 2016
Phase: N/A
Study type: Interventional

The goal of this study is to increase and improve Goals of Care discussions for advanced cancer patients by training medical oncologists to conduct these discussions. The investigators will evaluate the GoC discussion's effects on patient satisfaction, receipt of treatment in line with preferences, use of aggressive treatment, and oncologist communication skill.

NCT ID: NCT00510107 Recruiting - Stomach Neoplasm Clinical Trials

Weekly Docetaxel Plus Cisplatin or Oxaliplatin for AGC

Start date: July 2007
Phase: Phase 2
Study type: Interventional

To evaluate the efficacy and safety of weekly administered combination of docetaxel/cisplatin and docetaxel/oxaliplatin in chemotherapy-naïve patients with advanced gastric cancer. The primary endpoint will be the response rate.