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Stable Coronary Artery Disease clinical trials

View clinical trials related to Stable Coronary Artery Disease.

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NCT ID: NCT06123728 Recruiting - Clinical trials for Stable Coronary Artery Disease

MCG is Clinically Applied to Evaluate Myocardial Ischemic Function in Patients With Stable Coronary Artery Disease

Start date: April 19, 2023
Phase:
Study type: Observational [Patient Registry]

The objective of this observational study is to evaluate the diagnostic effectiveness of magnetocardiography (MCG) in patients with stable coronary artery disease (SCAD) and compare it with coronary CTA (CCTA). Additionally, the study aims to determine the most suitable diagnostic index for MCG. The primary question it seeks to address is whether MCG or MCG combined with CCTA can be utilized to guide the clinical application of percutaneous coronary intervention (PCI) for coronary heart disease.

NCT ID: NCT04434365 Active, not recruiting - Clinical trials for Percutaneous Coronary Intervention

Effect of Berberine for Endothelial Function and Intestinal Microflora in Patients With Coronary Artery Disease

Start date: June 21, 2019
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to conduct a single-center, randomized, open-label, controlled, dose-escalating, parallel-group study, evaluating the effects and change of endothelial function and gut microbiota after berberine administration in patients with stable coronary artery disease who are at > 8 but ≤ 40 weeks after elective percutaneous coronary intervention

NCT ID: NCT03782688 Completed - Clinical trials for Stable Coronary Artery Disease

Precise Percutaneous Coronary Intervention Plan (P3) Study

P3
Start date: February 1, 2019
Phase:
Study type: Observational [Patient Registry]

The PRECISE PERCUTANEOUS CORONARY INTERVENTION (PCI) PLAN STUDY is an investigator-initiated, international and multicenter study of patients with an indication for PCI aiming at assessing the agreement and accuracy of the HeartFlow Planner with invasive fractional flow reserve (FFR) as a reference.

NCT ID: NCT03384966 Completed - Clinical trials for Stable Coronary Artery Disease

A Medical Research Study to Evaluate the Effects of ACT-246475 in Adults With Coronary Artery Disease

Start date: January 24, 2018
Phase: Phase 2
Study type: Interventional

The goal of this study is to find out if a drug called selatogrel (ACT-246475) can prevent platelets from binding together when administered by an injection under the skin in the thigh or in the belly. Another goal is to know how fast and for how long selatogrel (ACT-246475) works and if there is a difference if the drug is injected in the thigh or in the belly. This study will also help to find out more about the safety of this new drug.

NCT ID: NCT03313752 Recruiting - Clinical trials for Type2 Diabetes Mellitus

Effects of SGLT2 Inhibition on Myocardial Insulin Sensitivity

DapaHeart
Start date: December 1, 2017
Phase: Phase 3
Study type: Interventional

A Phase III, single-centre, randomized, 2-arm, parallel-group, double blind, placebo-controlled study, consisting of a screening phase (Days -14 to -1), a 4-week double-blind, placebo-controlled treatment phase and a 4-week follow-up phase. Subjects: Type 2 diabetic patients and coronary artery diseases (CAD) not requiring revascularization or underwent percutaneous coronary intervention (PCI) but clinically stable at time of screening visit, with suboptimal glycaemic control (HbA1c 7.0-8.5%) on their current anti-hyperglycaemic regimen Subjects will be randomized in a 1:1 ratio to dapagliflozin or placebo. Subjects will undergo screening assessment in the 14-day period preceding administration of the first dose of study drug on Day 1. The primary Objective is to assess the effect of dapagliflozin on myocardial insulin sensitivity The Secondary Objective is to assess global heart function, and metabolic systemic effects of dapagliflozin, and glycemic control. The study aims to enroll patients with type 2 diabetes with suboptimal glycemic control, and with coronary artery diseases (CAD) not requiring revascularization or underwent percutaneous coronary intervention (PCI) but clinically stable, who have already undergone, under routine cardiological assessment, a positron emission tomography (PET) 13NH3 scan in order to assess the cardiovascular function. Thus, the study aims to assess whether the improvement in cardiac metabolism obtained with dapagliflozin is greater than that obtained with normal clinical practice (according to Standards of Care).

NCT ID: NCT03312855 Completed - Clinical trials for Stable Coronary Artery Disease

Intracoronary Stenting and Antithrombotic Regimen: Lesion Platelet Adhesion as Selective Target of Endovenous Revacept

ISAR-PLASTER
Start date: November 20, 2017
Phase: Phase 2
Study type: Interventional

The main objective is to evaluate the efficacy and safety of treatment with 2 doses (80 and 160 mg) of Revacept versus placebo in patients with stable coronary artery disease undergoing PCI.

NCT ID: NCT03089450 Recruiting - Clinical trials for Ischemic Heart Disease

To Evaluate Safety and Efficacy of CGBIO Stent Compared to Biomatrix Flex Stent

Start date: March 22, 2017
Phase: N/A
Study type: Interventional

to evaluate safety and efficacy of CGBIO stent(DES) compared to Biomatrix flex stent(DES)

NCT ID: NCT02580851 Completed - Quality of Life Clinical Trials

Magnetic Resonance Adenosine Perfusion Imaging as Gatekeeper of Invasive Coronary Intervention

MAGnet
Start date: December 2011
Phase: N/A
Study type: Interventional

Current guidelines for the diagnosis and management of patients with stable coronary artery disease (CAD) strongly support the performance of non-invasive imaging techniques for the detection of myocardial ischemia prior to revascularization procedures. This recommendation originates from the strong evidence base showing the lack of prognostic benefit from percutaneous coronary interventions (PCI) over optimal medical therapy in patients without verification of myocardial ischemia. On the other hand, it could be demonstrated that patients with functionally significant coronary artery stenoses do benefit from revascularization. Cardiac magnetic resonance imaging (CMR) has emerged to be a diagnostic modality of choice for the detection of myocardial ischemia with high sensitivity and specificity. The investigators therefore designed this prospective and randomized trial to compare a CMR-driven vs. angiography-driven management of patients with stable CAD concerning major cardiac endpoints, futile angiographies and quality of life.

NCT ID: NCT01609465 Active, not recruiting - Clinical trials for Stable Coronary Artery Disease

Prognostic Models for People With Stable Coronary Artery Disease

Start date: January 2010
Phase: N/A
Study type: Observational

There is currently no published algorithm for secondary prevention prognosis of CHD that is representative of the England GP-registered population and that includes both symptomatic and asymptomatic patients (as identified through primary care). In this paper the investigators will exploit routinely collected information in clinical practice to model CHD prognosis based on a large contemporary open cohort of stable CAD patients. Although the investigators model is based on data from GP practices in England only, the investigators believe that this population is sufficiently heterogeneous in terms of ethnic mix, socioeconomic background, predisposing characteristics and lifestyles to generate a prognostic model with good generalizing power to the wider population. Among the research questions the investigators will try to answer is whether established risk factors for primary care prevention (smoking, hypertension, dyslipidaemia, diabetes) are also reliable for risk-stratification of patients who have already developed CAD. Similarly, the investigators will examine whether strong predictors of adverse outcomes in ACS patients in the short term, such as admission SBP and heart rate, are also associated with their long term prognosis.

NCT ID: NCT01523392 Completed - Clinical trials for Stable Coronary Artery Disease

A Pharmacodynamic Study With Ticagrelor in African American Patients

Start date: March 2012
Phase: Phase 4
Study type: Interventional

The purpose of this study is to assess the pharmacodynamic effect of ticagrelor in African American patients with stable coronary artery disease.