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Clinical Trial Summary

Atezolizumab in patients with urinary tract squamous cell carcinoma: a single-arm, open-label, multicentre, phase II clinical trial


Clinical Trial Description

AURORA is a phase II open-label trial of Atezolizumab in patients with urinary tract squamous cell carcinoma (UTSCC). UTSCC is the most common of the rare urinary tract cancer histologies, comprising 2.1-6.7% of urinary tract cancers overall. There are few data available to guide treatment decisions for UTSCC. The AURORA trial will test the hypothesis that PD-L1 inhibition with atezolizumab immunotherapy is clinically effective, tolerable and safe, in patients with urinary tract squamous cell carcinoma (UTSCC). Translational endpoints will aim to determine characteristics for responsiveness to this treatment. AURORA was developed on behalf of the International Rare Cancers Initiative (IRCI) and the National Cancer Research Institute Bladder and Renal Group. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05038657
Study type Interventional
Source University Hospital Southampton NHS Foundation Trust
Contact Simon Crabb
Phone 02381203483
Email [email protected]
Status Not yet recruiting
Phase Phase 2
Start date January 2022
Completion date January 2025

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