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Impact of Ribociclib on Head and Neck Squamous Cell Cancer

Squamous Cell Carcinoma of the Head and Neck Clinical Trial

Official title:
Biomarker Window of Opportunity Study to Evaluate the Impact of Ribociclib on Head and Neck Squamous Cell Cancer

Clinical Trial Summary

A window of opportunity study which would allow brief treatment of HPV negative SCCHN with a CDK4/6 inhibitor, in the pre-operative setting, with biomarker analyses of pre and post treatment tissue. Given that the standard treatment for this population is surgical resection, this would not impact or alter standard therapy for this population. The goal will be to learn more about the alterations in pRB1 levels, as well as other signaling markers, in order to be able to eventually plan a biomarker driven treatment study.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03179956
Study type Interventional
Source Fox Chase Cancer Center
Contact
Status Terminated
Phase Early Phase 1
Start date April 2, 2018
Completion date January 10, 2019
View Details
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