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Hypoxia-based Dose Escalation With Radiochemotherapy in Head and Neck Cancer

Squamous Cell Carcinoma of the Head and Neck Clinical Trial

Official title:
Randomized Phase II Study for Dose Escalation in Locally Advanced Head and Neck Squamous Cell Carcinomas Treated With Radiochemotherapy

Clinical Trial Summary

Patients with locally advanced suqamous cell carcinoma of the head and neck region receive a hypoxia scan either by magnetic resonance tomography, computed tomography or fluoromisonidazole (FMISO)-PET-CT. Patients presenting with hypoxia are randomized into standard therapy consisting of intensity modulated radiotherapy (IMRT) with 70 Gy plus either 5-fluorouracil/mitomycin C or cisplatinum (Arm A) or a dose escalation of 10% (77Gy) to the hypoxic volume applied via simultaneous integrated boost in addition to the standard treatment (Arm B).

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02352792
Study type Interventional
Source University Hospital Tuebingen
Contact Daniel Zips, Prof. Dr. med.
Phone +49 7071 29 82141
Email daniel.zips@med.uni-tuebingen.de
Status Recruiting
Phase N/A
Start date December 2008
Completion date December 2022
View Details
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