| Eligibility |
Inclusion Criteria:
1. Male or female adult = 18 years of age.
2. Primary, histologically confirmed trunk or extremity (non- anogenital/-facial/-scalp)
isSCC lesion suitable for excision with a minimum diameter of 0.5 cm and with a
maximum diameter of 2.0 cm.
3. Histological diagnosis made no more than 6 months prior to the screening visit.
4. No other dermatological disease in the isSCC target site or surrounding area, which in
the opinion of the investigator, could interfere with the study.
5. Willing to refrain from using non-approved lotions or creams on the target site and
surrounding area during the treatment period.
6. Willing to refrain from exposure to excessive direct sunlight or ultraviolet light and
to avoid the use of tanning parlors for the duration of the study.
7. Laboratory values for the tests (listed in the Study Schedule) within the reference
ranges as defined by the central laboratory, or "out of range" test results that are
clinically acceptable to the investigator.
8. Ability to follow study instructions and likely to complete all study requirements.
9. Written informed consent obtained, including consent for tissue to be examined and
stored by the Central Histology Lab.
10. Written consent to allow photographs of the target isSCC lesion to be used as part of
the study data and documentation.
11. For females of childbearing potential, a negative pregnancy test at screening and
using an acceptable form of birth control (oral / implant/ injectable/ transdermal
contraceptives, intrauterine device, condom, diaphragm, abstinence, or a monogamous
relationship with a partner who has had a vasectomy).
Exclusion Criteria:
1. Pregnant, lactating, or planning to become pregnant.
2. Presence of known or suspected systemic cancer.
3. Histological evidence of severe squamous metaplasia, infiltrative, desmoplastic or
micronodular growth patterns in the biopsy specimen.
4. History of recurrence of the target isSCC lesion.
5. Concurrent disease or treatment that suppresses the immune system.
6. Patients with baseline QTC > 480 msec using Frederica's formula.
7. Chronic medical condition that in the judgment of the investigator(s) would interfere
with the performance of the study or would place the patient at undue risk.
8. Known sensitivity to any of the ingredients in the study medication including an
allergy to trehalose.
9. Use of a tanning bed or other excessive or prolonged exposure to ultraviolet light or
direct sunlight during the study.
10. Treatment with systemic chemotherapeutic agents within the 6 months prior to the
screening visit.
11. Use of systemic retinoids within the 6 months prior to the screening period.
12. Treatment with systemic immunomodulators or immunosuppressants within the 6 months
prior to the screening period.
13. Use of topical immunomodulators within 2 cm of the target isSCC lesion within the 4
weeks prior to the screening period.
14. Treatment with the following topical agents within 2 cm of the target isSCC lesion
within the 4 weeks prior to the screening visit: aminolevulinic acid, 5-fluorouracil,
corticosteroids, retinoids, diclofenac, ingenol mebutate, or imiquimod.
15. Treatment with liquid nitrogen, surgical excision or curettage within 2 cm of the
target isSCC lesion during the 4 weeks prior to the screening visit.
16. Evidence of current chronic alcohol or drug abuse.
17. Current enrollment in an investigational drug or device study or participation in such
a study within 4 weeks of the screening visit.
18. In the investigator's opinion, evidence of unwillingness, or inability to follow the
restrictions and requirements of the protocol and complete the study.
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