Rheumatoid Arthritis Clinical Trial
Official title:
Laboratory Research Study of the Immunosuppressive Effect of a Cell Therapy Product on PBMC Isolated From Blood of Patients With Inflammatory Rheumatic Diseases
Rheumatic diseases regroup a variety of disorders affecting the locomotor system including
joints, muscles, connective tissues and soft tissues around the joints and bones.
Inflammation and/or autoimmune reactions contribute to the aetiology of many rheumatic
diseases. Such autoimmune conditions, commonly referred to as inflammatory rheumatic diseases
(IRD), include arthritis of various origins such as rheumatoid arthritis (RA), psoriatic
arthritis (PsA) or spondylarthritis (SpA). Patients with autoimmune diseases such as RA or
SpA are in higher risk of fractures compared to the general population.
Initial pharmacotherapies for IRD remain NSAID treatment for pain relief, and anti-resorptive
agents (e.g., TNF-alpha blockers) which aim at reducing bone loss and preventing occurrence
of new bone erosions. Yet current treatments may have strong side effects and are not always
effective (e.g., 35-40% of the patients treated with TNF-alpha inhibitors will initially or
progressively loose response). Therefore there is a need for further treatment modalities in
IRD, which would focus on both suppressing inflammation and treating bone disorders.
Current research studies indicate that Bone Therapeutics' allogeneic osteoblastic cells
exhibit in vitro potent immunosuppressive and anti-inflammatory properties (in addition to
osteo-regenerative and immune-privileged properties).
The present research study aims at investigating in vitro the properties of these
osteoblastic cells in the context of inflammatory rheumatic diseases. In this purpose, in
vitro assays will be used to test these immunosuppressive effects on peripheral blood
mononuclear cells (PBMCs) of subjects diagnosed with RA, PsA and SpA.
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