Clinical Trials Logo

Spine Metastasis clinical trials

View clinical trials related to Spine Metastasis.

Filter by:
  • None
  • Page 1

NCT ID: NCT03853434 Recruiting - Blood Loss Clinical Trials

Efficacy of Angiographic Embolization vs Non-embolization of Moderate/Poor Vascularized Vertebral Metastases on Intraoperative Bleeding During Surgery Decompression and Vertebral Stabilization.

Embart
Start date: March 1, 2019
Phase: N/A
Study type: Interventional

Although angiographic embolization has been introduced for preoperative management of spine metastases in 1975 and is suggested today by many authors in the management of such pathologies, it needs to be confirmed by RCT. It is a minimally invasive procedure, not free from complications. The recent meta-analyzes, due to the limited number of patients included are not exhaustive about the effectiveness of embolization in the reduction of the intraoperative bleeding, especially in the context of poor / moderate metastasis vascularization. We want to evaluate the efficacy of preoperative angiographic embolization of intermediate / poor vascularized spine metastases in reducing intraoperative blood loss during excision surgery.

NCT ID: NCT03072979 Recruiting - Spine Metastasis Clinical Trials

A Study to Quantify Tumour Perfusion for Spine Metastasis Treated With Stereotactic Body Radiotherapy (SBRT)

Start date: January 21, 2017
Phase: N/A
Study type: Observational

Pre-clinical evidence suggests that radiotherapy reduces tumour-associated vasculature. The investigators will conduct a single-arm prospective study to quantify the reduction in tumour vasculature post-radiotherapy

NCT ID: NCT02700308 Terminated - Solid Tumors Clinical Trials

A Study of Kyphoplasty and Vertebroplasty in the Treatment of Spine Metastases

KYPHO-01
Start date: March 2016
Phase: Phase 2
Study type: Interventional

Conventional vertebroplasty is an effective option in the treatment of bone lesions (osteoporotic and neoplastic). It is indicated as an analgesic treatment and aims at reinforcing a compressed vertebrae or at risk of fracture. The main adverse event related to vertebroplasty use is the cement leakages that might be responsible for significant clinical impairments. Kyphoplasty is a recent alternative strategy of vertebroplasty, based on the insertion on balloon through the needle into the targeted vertebrae and then inflation of the balloon prior to cement injection into the space. In an osteoporotic setting, kyphoplasty allow reducing the incidence of cement leakage. To date, no data from randomized study are available in the population of cancer patients.

NCT ID: NCT02242786 Recruiting - Clinical trials for Hepatocellular Carcinoma

Diffusion-Weighted Magnetic Resonance Imaging

Start date: August 2014
Phase: Phase 2
Study type: Interventional

Recently, diffusion-weighted (DW) MR imaging has widened its application on various oncologic applications. Especially, it is expected the DW MRI could provide valuable information about early response evaluation after treatment using rapid apparent diffusion coefficient (ADC) value change. It has demonstrated potential usefulness in response evaluation in the liver tumors after treatments such as transarterial chemoembolization (TACE) and radiation therapy (RT). Furthermore, it is a functional imaging technique that does not require a contrast agent, it can be safely used in patients with renal insufficiency or other medical contraindications for contrast agents. The optimal assessment of early response of RT could provide one of the most important information to prescribe patient and cancer specific RT dose. It might be also important in palliative RT of HCC bone metastasis which is related with painful aggressive mass formation. This study is performed to evaluate the usefulness of DW MRI in early response evaluation after RT for HCC bone metastasis.

NCT ID: NCT01231061 Completed - Spine Metastasis Clinical Trials

Spinal met_radiosurgery/SBRT Study

Start date: November 2010
Phase: Phase 2
Study type: Interventional

Demonstrate the technical feasibility of treating spine metastases with image-guided radiosurgery/SBRT

NCT ID: NCT00928382 Completed - Cancer Clinical Trials

A Pilot Study to Explore Serum and Imaging Biomarkers in Patients With Spinal Cord Compression

Start date: March 31, 2009
Phase: N/A
Study type: Observational

One of the complications of having cancer in the spinal vertebrae is that it can spread and lead to compression of the spinal cord. Spinal cord compression is a serious event that needs to be treated quickly in order to prevent permanent damage to the spinal cord and nerves. - Researchers currently do not have the ability to accurately predict whether cancer of the vertebrae will cause spinal cord compression. It is possible that accurate predictions could allow doctors to treat patients even before they develop symptoms of spinal cord compression, thereby preventing some of the long-term consequences. Objectives: - To compare patients with cancer of the spinal vertebrae with and without symptoms of spinal cord compression by looking at markers in the blood and changes on novel magnetic resonance imaging (MRI) techniques that might allow researchers to predict who will experience spinal cord compression before they actually begin to have symptoms. Eligibility: - One group of healthy volunteers 18 years of age and older. - One group of patients 18 years of age and older who have cancer that has spread to the vertebrae without symptoms of spinal cord compression. - One group of patients 18 years of age and older who have cancer that has spread to the vertebrae with symptoms of spinal cord compression. Design: - Healthy volunteers: - Blood will be drawn from each volunteer for initial tests and for more specific biomarker tests. - Comprehensive MRI of the spine, followed by a special type of MRI called diffusion tensor imaging (DTI). It is believed that DTI may be even more sensitive in revealing spinal cord abnormalities than regular MRI sequences. - Patients with cancer of the vertebrae: - Researchers will obtain information such as pathology reports, laboratory results, diagnosis and treatment history, physical exam (PE) information, results of scans such as x-rays, MRI, computerized tomography (CT), and positron emission tomography (PET), and planned treatment details. - Additional blood samples will be taken for specific biomarker tests. - Questionnaire about pain, unusual sensations or numbness, bladder or bowel problems, and mobility. - Comprehensive MRI of the spine, followed by a DTI. - Patients who appear to have symptoms of spinal cord compression will be offered standard radiation treatment.