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Prophylactic Radiotherapy of MInimally Symptomatic Spinal Disease — PROMISSeD  

Spine Metastases Clinical Trial

Official title:
Prophylactic Radiotherapy of MInimally Symptomatic Spinal Disease (PROMISSeD Trial)

Clinical Trial Summary

Early palliative care has been shown to improve the quality of life and even survival for patients with metastatic cancer. More and more supportive oncology teams in cancer centers now advocate for early integration of radiation therapy (RT) in a patient's palliative management course. While multiple randomized studies have evaluated the efficacy of different RT regimens in the treatment of symptomatic bone lesions, few studies have examined the impact of early, upfront RT for asymptomatic or minimally symptomatic (non- opioid dependent) spine metastases and its efficacy in preventing skeletal-related events (SREs). Since the pathophysiology of spinal metastatic disease is distinct from other bony metastatic disease, the proposed trial seeks to understand whether it is beneficial to patients with minimally symptomatic disease to undergo upfront RT to reduce the risks of SREs and their sequelae, including hospitalizations.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05534321
Study type Interventional
Source Baptist Health South Florida
Contact Rupesh R Kotecha, MD
Phone 17865962000
Email rupeshk@baptisthealth.net
Status Recruiting
Phase Phase 1/Phase 2
Start date August 29, 2022
Completion date September 2027
View Details
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