Spine Fusion Clinical Trial
Official title:
Personalized Perioperative Analgesia Platform (PPAP) for Pediatric Spine Fusion Surgery (sIRB)
The purpose of this collaborative CTSA application is to develop an innovative perioperative precision analgesia platform (PPAP) to improve analgesia and reduce serious immediate and long-term adverse outcomes of perioperative opioids in children undergoing painful surgery.
Aim 1. Develop and implement a perioperative precision analgesia platform (PPAP) by linking genomics to opioid metabolism, CPIC guidelines, precision dosing, clinical safety, and personalizing analgesia Aim 2. Implement and evaluate PPAP in children undergoing major inpatient surgery, posterior spinal fusion (PSF) 1. Determine genetic factors predisposing children to immediate and long-term postoperative methadone and oxycodone related adverse effects including RD, PONV, opioid dependence, and CPSP The investigators postulate that specific CYP2B6, ABCB1, OPRM1, FAAH, and CYP2D6 variants identify children at risk for poor pain relief, RD, PONV, opioid dependence, and CPSP in the postoperative period. 2. Determine genetic variants-based perioperative dosing and outpatient prescribing of opioids The investigators hypothesize that CYP2B6 and CYP2D6 variants will explain pharmacokinetic variations of methadone and oxycodone, determine the right doses, and implement precision opioid use for optimal clinical outcomes ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04095624 -
Does Preoperative Pain Medication Management Influence Surgical Outcomes in Spinal Fusion
|
N/A | |
| Terminated |
NCT03426137 -
Relieving Acute Pain (RAP) Study: A Pilot Study
|
Phase 2 | |
| Active, not recruiting |
NCT04629807 -
Anterior Gen Plus Study
|
N/A | |
| Active, not recruiting |
NCT04379921 -
Improving Spine Surgical Care With Real-Time Objective Patient Tracking Using the Apple Watch
|
N/A | |
| Completed |
NCT02280187 -
InductOs® in Real World Spine Surgery; A Retrospective, French, Multi-centric, Study
|
N/A | |
| Completed |
NCT06082245 -
TLIP Block and ESP Block For Perioperative Analgesia In Patients With Lumbar Spine Fusion Surgery
|
N/A | |
| Recruiting |
NCT06102681 -
Examination of the Effect of Early Mobilization on Postoperative Recovery, Pain, Quality of Life and Complication Development in Elective Minimally Invasive Spine Surgery
|
N/A | |
| Recruiting |
NCT06059820 -
Effectiveness of Conservative Treatment in Patients With Thoracic and Lumbar Fractures Without Neurological Deficit
|
||
| Active, not recruiting |
NCT05001893 -
Clinical Safety and Efficacy of S53P4 Bioactive Glass Putty in Spinal Fusion Surgery
|
||
| Completed |
NCT04711668 -
Effect of Introperative Ketamine and Lidocaine Infusion on Postoperative Opioid Consumption in Posterior Spinal Fusion Surgery
|
N/A | |
| Not yet recruiting |
NCT05850468 -
Effectiveness of Combining Erector Spinea Block With Non Opioid Infusions as Opioid Free Anesthesia in Spine Surgeries.
|
N/A | |
| Completed |
NCT04682418 -
Pedicle Screw Placement With XVS
|
N/A | |
| Not yet recruiting |
NCT06393530 -
Erector Spinae Plane Block for Cervical Spine Surgery
|
Phase 4 | |
| Not yet recruiting |
NCT04679844 -
Post Marketing Study of MagnetOs Putty Compared to Demineralized Bone Matrix (DBM) Mixed With Autograft in Patients Undergoing Posterolateral Lumbar Fusion
|
N/A | |
| Not yet recruiting |
NCT04568837 -
Steroids After Spine Fusion Surgery
|
Phase 4 | |
| Completed |
NCT05401526 -
Fluid Responsiveness in Prone Position
|
||
| Not yet recruiting |
NCT06450834 -
Ostene in Thoracolumbar Decompression and Fusion Evaluated With VIBE
|
||
| Not yet recruiting |
NCT05037968 -
MagnetOs Flex Matrix Compared to Cell Based Allografts in Patients Undergoing up to Four-level Instrumented Posterolateral Fusion
|
N/A | |
| Not yet recruiting |
NCT05691062 -
Titanium vs. PEEK Fusion Devices in 1 Level TLIF
|
Phase 4 | |
| Recruiting |
NCT04839783 -
Single Position Spine Surgery Registry
|