Spinal Tumors, Trauma Patients, Minocycline. Clinical Trial
Spinal cord trauma and the consequent paraplegia are possibly among the most devastating
injuries in soldiers and during spine surgery, and are significant in the medical, social
and financial aspects. Limited mobility, the need for assistance in all human activities,
shame, and many medical complications related directly to the neural deficits make
paraplegia an important target for prevention. Our study will evaluate the efficacy of
Minocycline in two different groups:
1. Minimizing the neurological damage among trauma patients.
2. Preventing neurological damage through operation in spinal tumors patients.
2.OBJECTIVES
The primary objectives of the trial are to determine:
1. Efficacy of administrating minocycline in minimizing the neurological damage among
acute spinal cord injury patients and spinal cord tumors (primary and metastases)
patients?
2. Efficacy of administrating minocycline at changing the natural history and
rehabilitation of spinal cord trauma patients.
3. Safety of applying minocycline in spinal cord injuries patients and spinal cord tumors?
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention