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Effects of Different Anesthetic Gases on Hemodynamics, Arterial Oxygenation and Lung Mechanics

Spinal Surgery Clinical Trial

Official title:
Evaluation of the Effects of Different Anesthetic Gases on Hemodynamics, Arterial Oxygenation and Lung Mechanics in Spinal Surgery.

Clinical Trial Summary

The bronchodilator effects of volatile anesthetics have been the subject of many clinical studies. It is known that all volatile anesthetics, especially halothane, have similar effects. Sevoflurane has been shown to reduce airway resistance more than halothane and isoflurane. Desflurane is difficult to use as an induction agent due to its harsh and extremely pungent odor and airway irritating effect. However, it has been shown that the risk of cough, respiratory arrest and laryngospasm is no different from sevoflurane when administered after intravenous induction. Although it irritates the airway, it is thought to have a bronchodilation effect as it stimulates the sympathetic system. In spinal surgeries, prone position is required to access the operating field. When the patient is placed in the prone position, pulmonary physiology are affected. In the prone position, V/Q mismatch decreases and arterial oxygenation increases. However, lung compliance decreases and the peak inspiratory pressure required to reach the required tidal volume increases. The main purpose of this study is the effect of volatile agents on lung mechanics and oxygenisation in the prone position.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06118489
Study type Observational
Source Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Contact
Status Completed
Phase
Start date December 1, 2023
Completion date February 1, 2024
View Details
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