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Spinal Stenosis clinical trials

View clinical trials related to Spinal Stenosis.

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NCT ID: NCT06407063 Active, not recruiting - Clinical trials for Degenerative Lumbar Spondylolisthesis

Long-term Reoperations After Lumbar Spinal Stenosis Surgery

Start date: September 19, 2007
Phase:
Study type: Observational [Patient Registry]

Severe and persisting pain and disability due to a degenerative narrowing of the spinal canal, lumbar spinal stenosis, can be operated with a simple surgical decompression. Sometimes, there is also a slippage of vertebra, degenerative spondylolisthesis. In such cases, instrumental stabilization (e.g. screws and rods) has been recommended. Even though additional fusion is more complex and riskier, and evidence in high-quality Scandinavian studies shows that it is unnecessary, decompression plus fusion is still the treatment of choice in the USA and most European countries. This reluctance to change clinical practice is mainly due to concerns about long-term results, especially higher reoperation rates among patients operated with decompression only. This register-based non-inferiority study aims to assess long-term reoperations among those treated with and without additional fusion surgery.

NCT ID: NCT06365229 Active, not recruiting - Clinical trials for Lumbar Spinal Stenosis

Percutaneous Unilateral Biportal Endoscopy Versus Uniportal Endoscopy for Lumbar Spinal Stenosis: Study Protocol

Start date: January 1, 2023
Phase:
Study type: Observational [Patient Registry]

A prospective study aimed to compare the efficacy and safety of Unilateral biportal endoscopic (UBE) technique and uniportal endoscopic (UE) technique for treating patients with lumbar spinal stenosis (LSS).

NCT ID: NCT05309447 Active, not recruiting - Clinical trials for Lumbar Spinal Stenosis

Effect of Muscle Fatigue on Spinal Imbalance and Motion in Lumbar Spinal Stenosis

MuscLSS
Start date: November 11, 2021
Phase:
Study type: Observational

This study assesses spinal imbalance and motion in patients with sLSS and elicits fatigue via back exercises and compares spinal imbalance and motion before and after the fatigue exercise and compares these to healthy controls, allowing to associate sLSS-specific motion patterns to paraspinal muscle fatigue.

NCT ID: NCT05273879 Active, not recruiting - Clinical trials for Lumbar Spinal Stenosis

Necessity of Fusion Following Decompression Surgery in Patients With Single-level Lumbar Stenosis

Start date: April 1, 2022
Phase: N/A
Study type: Interventional

Long-term clinical results of two methods of surgical treatment (spinal decompression with or without fusion) in patients with single-level lumbar stenosis will be compared. A clear framework for surgical treatment methods and standardized postoperative rehabilitation treatment will be set to obtain the maximum homogeneity of the patient groups. This trial should provide the first level of evidence for the need for spinal fusion in patients with single-level lumbar stenosis, subject to the high homogeneous comparison groups. Additional results will allow comparing the economic aspects of different surgical treatments for 2 years after surgery.

NCT ID: NCT05242497 Active, not recruiting - Clinical trials for Lumbar Spinal Stenosis

Effectiveness and Safety of Pharmacopuncture Therapy for Patients With Lumbar Spinal Stenosis

Start date: April 13, 2022
Phase: N/A
Study type: Interventional

This is 1:1 pragmatic randomized controlled trials in a parallel-grouped, multi-centered design that investigated pharmacopuncture therapy for patients with lumbar spinal stenosis, compared to the conservative treatments including physiotherapy and pharmacological treatments.

NCT ID: NCT05114135 Active, not recruiting - Clinical trials for Degenerative Disc Disease

TLIF Osteo3 ZP Putty Study (Also Known as the TOP Fusion Study)

Start date: September 7, 2021
Phase: N/A
Study type: Interventional

In recent years there has been an increase in interest from surgeons in the use of synthetic bone graft substitutes to avoid the need of sourcing allograft or iliac crest autograft for use in spinal fusion procedures. This will be an open label, prospective, first in man, single-centre clinical study to evaluate the safety and performance of Osteo3 ZP Putty synthetic bone graft in TLIF procedures with instrumented PLF. Safety and performance data obtained in this clinical study will be used to estimate clinical success rates achieved with the use of Osteo3 ZP Putty synthetic bone graft in TLIF procedures. No comparative control group is intended. The study is expected to run for approximately three years with each subject being followed up for a two- year post-operative period. The target is to recruit approximately 17 subjects to this clinical study, allowing for some subject attrition to get 15 evaluable.

NCT ID: NCT04653675 Active, not recruiting - Cardiac Amyloidosis Clinical Trials

Cardiac Amyloidosis in Spinal Stenosis: the CASS-study

CASS
Start date: January 1, 2021
Phase:
Study type: Observational

Background: A significant portion of cardiac amyloidosis patients have a 5 to 10 years prior history of spinal canal stenosis, reflecting a diagnostic red flag that should raise suspicion for amyloidosis presence. Mild troponin release and NT-proBNP elevation, both serum cardiac biomarkers, often coincide with cardiac amyloidosis. Early cardiac amyloidosis treatment improves survival, warranting timely diagnosis. Study aim: to test a prospective screening strategy, based on serum cardiac biomarkers, to increase early detection of cardiac amyloidosis in patients with spinal canal stenosis. Design: Single-centre prospective observational non-interventional diagnostic study. Methods: Consecutive patients during a one-year period in AZ Sint-Jan Bruges, without known cardiac amyloidosis history and scheduled for spinal canal stenosis surgery, will have cardiac evaluation including serum cardiac biomarker (high-sensitive troponin T and NT-proBNP) assessment, electrocardiography and transthoracic echocardiography. During surgery, all patients will undergo ligamentum flavum biopsy to evaluate presence and burden of transthyretin amyloid deposition (Congo-red staining and immune histochemistry). All patients with suspicion for cardiac amyloidosis will undergo further diagnostic testing (including laboratory test and bone scintigraphy). A chronologic cascade screening process will be used starting with abnormal serum cardiac biomarkers (high-sensitive troponin T ≥ 14 ng/ml and/or NT-proBNP > 125 pg/ml), followed by electrocardiography, transthoracic echocardiography and finally ligamentum flavum biopsy results. The diagnostic performance of this biomarker-based strategy will be compared to electrocardiography, echocardiography and ligamentum flavum biopsy. Conclusion: It is hypothesised that serum cardiac biomarker testing in patients undergoing spinal canal stenosis surgery represents a simple and valuable prospective screening strategy for early detection of cardiac amyloid(osis).

NCT ID: NCT04594980 Active, not recruiting - Clinical trials for Lumbar Spinal Stenosis

Minimally Invasive Decompression and Fusion Versus Open for Degenerative Lumbar Stenosis

Start date: January 20, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to determine the effectiveness of minimally invasive decompression and fusion over the traditional open decompression and fusion in patients with single-level lumbar stenosis caused by degenerative spondylolisthesis. Postoperative follow-up will continue for 12 months. Сlinical, safety, radiological and cost-effectiveness endpoints will be evaluated.

NCT ID: NCT04559295 Active, not recruiting - Low Back Pain Clinical Trials

Bone Marrow Concentrate (BMC) Injection in Intervertebral Discs

Start date: November 21, 2018
Phase: Phase 2/Phase 3
Study type: Interventional

Intradiscal delivery of bone marrow concentrate (BMC) into discs, facet, epidural space, and sacroiliac joints

NCT ID: NCT04492774 Active, not recruiting - Clinical trials for Spinal Stenosis Lumbar

Degenerative Lumbar Stenosis Conservative Treatment

GOLDSTEN
Start date: July 1, 2020
Phase: Phase 4
Study type: Interventional

The trial aims to compare the effectiveness of three methods of conservative treatment of degenerative lumbar spine stenosis (DLSS): GOLDIC autologous serum epidural injections, steroid epidural injections and manual therapy.