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Clinical Trial of Pregabalin and COX2 in Spinal Stenosis

Spinal Stenosis Lumbar Clinical Trial

Official title:
Comparative Study for Decrease of Pain Intensity and Pain Sensitivity Between Pregabalin + COX-2 Inhibitor and COX-2 Inhibitor in Patients With Lumbar Spinal Stenosis: Randomized Controlled Trial

Clinical Trial Summary

Aim of this prospective, single-blind, randomized study was to compare the efficacy of the combination of celecoxib and pregabalin and celecoxib only monotherapy for treatment of chronic low-back pain.

Clinical Trial Description

The efficacy and safety of the association of celecoxib [a selective cyclooxygenase-2 (COX-2) inhibitor] and pregabalin (commonly used to control neuropathic pain), compared with monotherapy of each, were evaluated for the treatment of chronic low-back pain, a condition known to be due to neuropathic as well as nociceptive pain mechanisms.

We will compare the efficacy of the combination of a selective COX-2 inhibitor (celecoxib) and an antineuropathic drug, pregabalin, versus celecoxib only monotherapy, in the treatment of spinal stenosis.

Each treatment lasted 8 weeks

Primary outcome is mean pain reduction following different treatments regimes. Secondary outcomes are the changes of pain sensitivity, Oswestry disability index, adverse effects due to the treatments under study. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03584074
Study type Interventional
Source Seoul National University Bundang Hospital
Contact Ho-Joong Kim, M.D., Ph.D
Phone +82317872300
Email oshjkim@gmail.com
Status Not yet recruiting
Phase Phase 4
Start date July 1, 2018
Completion date December 31, 2019
View Details
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