Spinal Cord Injury Clinical Trial
Official title:
Neurofeedback Treatment of Central Neuropathic Pain (CNP) in Sub-acute Patients With Spinal Cord Injury (SCI)
Spinal Cord Injury (SCI) affects a person's ability to move and feel sensation in the body.
SCI is also an indirect cause of a persistent pain, called Central Neuropathic Pain (CNP).
This pain typically develops several months after the injury. In 30-40% of SCI patients,
severe CNP affects their everyday living including sleep and mood. Many patients give up
work, not because of the injury, but because of pain. Medical treatment of CNP is moderately
effective and costly, both to the patient and to the health care system.
In previous research, characteristic 'signatures' of brain waves that are probably related to
CNP have been defined. Based on this, a novel treatment for CNP based on neurofeedback was
developed and clinically tested on five SCI patients. Electroencephalograph (EEG) was used to
record patients' brain waves and these were shown to patients on a computer screen in a
simple graphical form (e.g. bars). Patients were trained to change their brain activity at
will and, as a consequence, their pain was reduced. Patients who had suffered from CNP for
years received up to 40 neurofeedback treatment sessions, reducing their pain for several
days after each session.
The primary aim of this study is to apply neurofeedback therapy to a larger number of
recently injured patients, who are still in a hospital. It is hypothesised that neurofeedback
treatment will be more effective in people who have suffered from CNP for a shorter period of
time.
The secondary aim of the study is to define EEG predictors of CNP. EEG will be recorded in
recently injured patients with no chronic pain, knowing that a certain number of patients
will develop CNP within weeks or months. These patients will be followed up for a year and
the EEGs of patients who develop CNP will be compared with those who do not.
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