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Spinal Cord Injury clinical trials

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NCT ID: NCT06309888 Recruiting - Spinal Cord Injury Clinical Trials

Magnetic Resonance Imaging of Cognitive Deficits in the Brain of Individuals With Spinal Cord Injury

SCI_Cog
Start date: February 1, 2024
Phase:
Study type: Observational

In the case of spinal cord injury, rehabilitation is particularly focused on motor skills. Non-motor impairments such as thinking difficulties did not receive a lot of attention to date. In this research project, the investigators want to find out how thinking difficulties become noticeable in the brain with spinal cord injury. Participation procedure: Participants who take part will be asked to come to an examination once. The duration of the examination is between 2 and 2.5 hours (including around 55 minutes in the magnetic resonance imaging scanner, including preparation and follow-up).

NCT ID: NCT06130449 Recruiting - Spinal Cord Injury Clinical Trials

Testosterone and Neural Function

Start date: April 1, 2024
Phase: Early Phase 1
Study type: Interventional

Spinal cord injury (SCI) disrupts the nerves controlling movement, along with those that regulate functions like heart rate and blood pressure (known as the autonomic nervous system, or ANS). Testosterone (T) plays a significant role in brain health and ANS reflex function in non-neurologically impaired men. However, little is known about the relationships between T, nerve function, and ANS dysfunction after SCI. Interestingly, up to 60% of men with SCI exhibit persistently low T concentrations, which may worsen nerve and ANS dysfunction. In uninjured eugonadal people (normal physiologic range of serum T concentrations), a single pharmacologic dose of intranasal T has been shown to quickly improve nerve function, but no study has evaluated if T administration alters nerve and ANS function in men with SCI. Herein, the investigators will conduct the first study to test how a single dose of intranasal T impacts motor and ANS function in this population.

NCT ID: NCT06040749 Recruiting - Spinal Cord Injury Clinical Trials

Virtual Sport for Adults ≥ 50 Years With Spinal Cord Injury

Start date: May 5, 2023
Phase: N/A
Study type: Interventional

Sport is a physical activity that has many physical, psychological and social benefits for those with spinal cord injury (SCI). However, most sport research involves people with SCI who are <50 years old. This is a problem because many people are >50 years old when first injured. Moreover, people with a SCI are now living longer lives, meaning they also experience more health challenges. Unfortunately, there is limited research studying the impact of sport for adults with SCI aged ≥50 years old.

NCT ID: NCT05941819 Recruiting - Spinal Cord Injury Clinical Trials

ARC Therapy to Restore Hemodynamic Stability and Trunk Control in People With Spinal Cord Injury

HemON-NL
Start date: September 5, 2023
Phase: N/A
Study type: Interventional

The goal of this interventional study is to evaluate the safety and preliminary effectiveness of the ARC-IM Therapy to improve hemodynamic management in people with sub-acute or chronic spinal cord injury. Participants will be implanted with the ARC-IM Thoracic System which aim to deliver, at the low thoracic level, targeted epidural electrical stimulation that will support natural hemodynamic control.

NCT ID: NCT05887752 Recruiting - Spinal Cord Injury Clinical Trials

Hunova® Randomized Controlled Trial for Trunk Control Improvement in Spinal Cord Injured Patients

Start date: June 5, 2023
Phase: N/A
Study type: Interventional

In patients with Spinal Cord Injury (SCI), trunk and therefore postural control (both in statics and dynamics) are impaired, often with strong consequences on daily life activities. Therefore, improvement and reinforcement of trunk control are primary rehabilitation (rehab) goals. For the evaluation of trunk control in SCI people, still today no tests and scales are definable as gold standards. Nowadays, for evaluation and rehab purposes of trunk control, balance and proprioception, in both sitting and standing positions, conventional rehabilitation can be supplemented with robotic treatments, e.g. through the Hunova® device (by Movendo Technology). Several studies have demonstrated that conventional rehab associated with robotic training is able to influence functional and motor outcomes in stroke patients, while little evidence is available on SCI patients, also on the number of robotic sessions needed. The present randomized controlled study primarily aims to demonstrate the effects on trunk control of an integrated rehab treatment (standard plus Hunova®), compared to the standard alone and to gain evidence on the better rehabilitation scheme in terms of number of Hunova® sessions. The correlation between the variation of trunk control, measured by the output data of the Hunova® device itself - ideally more objective - and that assessed through a validated clinical scale, will also be estimated.

NCT ID: NCT05805683 Recruiting - Spinal Cord Injury Clinical Trials

Calcitonin Therapy on Incidence and Severity of Neuropathic Pain After Spinal Cord Injury

Start date: May 1, 2023
Phase: N/A
Study type: Interventional

This prospective randomized double blinded study will be conducted to evaluate the effect of early pharmacologic intervention with calcitonin on the incidence or the severity of neuropathic pain after spinal cord injury

NCT ID: NCT05664646 Recruiting - Spinal Cord Injury Clinical Trials

Autonomic Effects of Stimulation in SCI

Start date: July 24, 2023
Phase: N/A
Study type: Interventional

This study aims to determine the effects of transcutaneous spinal cord stimulation to increase blood pressure and use that device to increase exercise endurance time and heart rate recovery during arm cycle ergometry. In addition, the investigators will see if the stimulation helps regulate body temperature when in a cool environment.

NCT ID: NCT05638191 Recruiting - Spinal Cord Injury Clinical Trials

Nerve Transfer Surgery to Restore Upper-limb Function After Cervical Spinal Cord Injury

Start date: June 3, 2021
Phase:
Study type: Observational [Patient Registry]

The goal of this prospective, open label cohort study is to assess functional and motor outcomes in individuals with cervical spinal cord injury who have undergone nerve transfer surgery, with the goal of increasing upper limb function. We will also compare these outcomes to a cohort of similarly matched individuals who have not undergone nerve transfer surgery, using robust outcome measures, rigorous pre-operative clinical and neurophysiological assessments, and standardized rehabilitation. At the end of this project we aim to develop a model for predicting nerve transfer outcomes using pre-operative clinical and neurophysiological characteristics.

NCT ID: NCT05447676 Recruiting - Spinal Cord Injury Clinical Trials

Effects of 4-AP on Functional SCI Recovery

Start date: June 30, 2022
Phase: Early Phase 1
Study type: Interventional

The purpose of this study is to test a strategy to potentiate functional recovery of lower limb motor function in individuals with spinal cord injury (SCI). The FDA approved drug, Dalfampridine (4-AP). 4-AP will be used in combination of Spike-timing-dependent plasticity (STDP) stimulation and STDP stimulation with limb training.

NCT ID: NCT05433064 Recruiting - Spinal Cord Injury Clinical Trials

Spinal Cord Stimulation for Spinal Cord Injury Patients - Regain Walk and Alleviate Pain

Start date: May 1, 2020
Phase: N/A
Study type: Interventional

The study aims to examine the plausible interventional mechanisms underlying the effects of epidural spinal cord stimulation.