Clinical Trials Logo
  1. Home
  2. Spinal Cord Injuries
  3. NCT06066918
  4. Details
NCT06066918 Clinical Trial

Prophylactic Pregabalin Treatment Following Spinal Cord Injury

Spinal Cord Injuries Clinical Trial

Official title:
The Effect of Preventional Drug Therapy on Pain Regulation Mechanisms Among Spinal Cord Injury Patients Who Have Yet to Develop Central Pain

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT06066918
Other study ID # 0012-19-LOE
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date July 13, 2021
Est. completion date February 5, 2026

Study information
Verified date October 2023
Source Loewenstein Hospital
Contact Amiram Catz, Dr
Phone 972-9-770-9934
Email amiramc@clalit.org.il
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Patients arriving to rehabilitation up to 2 months following SCI will be given (study group) or not (control group) Lyrica (75X2). They will be followed for central pain development.

Description:

Patients arriving to rehabilitation up to 2 months following SCI will be recruited, if they have not yet developed central pain. Two thirds (the study group) will be treated with Lyrica (Pregabalin75X2) for 3 months. One third (the control group) will not receive preventative treatment. Participants will be followed for central pain development.

Recruitment information / eligibility
Status Recruiting
Enrollment 50
Est. completion date February 5, 2026
Est. primary completion date February 5, 2025
Accepts healthy volunteers No
Gender All
Age group 18 Years to 70 Years
Eligibility Inclusion Criteria: - spinal cord injury / lesion below C3. - up to 2 months from onset Exclusion Criteria: - Pregnancy - other medical conditions that might influence sensation - pain (chronic or acute) - Creatinine>1.2 mg/DL - Lactose sensitivity

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Pregabalin 75mg
Pregabalin 75 mg twice a day

Locations
Country Name City State
Israel Loewenstein Rehabilitation Hospital Ra'anana

Sponsors (1)
Lead Sponsor Collaborator
Loewenstein Hospital

Country where clinical trial is conducted

Israel, 

Outcome
Type Measure Description Time frame Safety issue
Primary Central pain development of central pain 1 year
See also
  Status Clinical Trial Phase
Active, not recruiting NCT06321172 - Muscle and Bone Changes After 6 Months of FES Cycling N/A
Completed NCT03457714 - Guided Internet Delivered Cognitive-Behaviour Therapy for Persons With Spinal Cord Injury: A Feasibility Trial
Recruiting NCT05484557 - Prevention of Thromboembolism Using Apixaban vs Enoxaparin Following Spinal Cord Injury N/A
Suspended NCT05542238 - The Effect of Acute Exercise on Cardiac Autonomic, Cerebrovascular, and Cognitive Function in Spinal Cord Injury N/A
Recruiting NCT05503316 - The Roll of Balance Confidence in Gait Rehabilitation in Persons With a Lesion of the Central Nervous System N/A
Not yet recruiting NCT05506657 - Early Intervention to Promote Return to Work for People With Spinal Cord Injury N/A
Recruiting NCT04105114 - Transformation of Paralysis to Stepping Early Phase 1
Recruiting NCT03680872 - Restoring Motor and Sensory Hand Function in Tetraplegia Using a Neural Bypass System N/A
Completed NCT04221373 - Exoskeletal-Assisted Walking in SCI Acute Inpatient Rehabilitation N/A
Completed NCT00116337 - Spinal Cord Stimulation to Restore Cough N/A
Completed NCT03898700 - Coaching for Caregivers of Children With Spinal Cord Injury N/A
Recruiting NCT04883463 - Neuromodulation to Improve Respiratory Function in Cervical Spinal Cord Injury N/A
Active, not recruiting NCT04881565 - Losing Balance to Prevent Falls After Spinal Cord Injury (RBT+FES) N/A
Completed NCT04864262 - Photovoice for Spinal Cord Injury to Prevent Falls N/A
Recruiting NCT04007380 - Psychosocial, Cognitive, and Behavioral Consequences of Sleep-disordered Breathing After SCI N/A
Active, not recruiting NCT04544761 - Resilience in Persons Following Spinal Cord Injury
Terminated NCT03170557 - Randomized Comparative Trial for Persistent Pain in Spinal Cord Injury: Acupuncture vs Aspecific Needle Skin Stimulation N/A
Completed NCT03220451 - Use of Adhesive Elastic Taping for the Therapy of Medium/Severe Pressure Ulcers in Spinal Cord Injured Patients N/A
Recruiting NCT04811235 - Optical Monitoring With Near-Infrared Spectroscopy for Spinal Cord Injury Trial N/A
Recruiting NCT04736849 - Epidural and Dorsal Root Stimulation in Humans With Spinal Cord Injury N/A