Rehabilitation and Cortical Remodeling After Surgical Intervention for Spinal Cord Injury

Spinal Cord Injuries Clinical Trial

Official title:

Rehabilitation and Cortical Remodeling After Surgical Intervention for Spinal Cord Injury

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04041063
• Other study ID #: SCI_nerve_transfer_robotics
• Status: Recruiting
• Phase: Phase 2
• Start date: July 26, 2019
• Est. completion date: December 31, 2026

Study information

• Verified date: June 2022
• Source: Burke Medical Research Institute
• Contact: Liz Magier, MPA
• Phone: 914.368.31159
• Email: elm2045[@]med.cornell.edu
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of this study is to determine the effects of rehabilitation on dexterous hand movements and cortical motor map changes in tetraplegic patients following nerve transfer surgery. The working hypothesis is that robot-assisted, intensive rehabilitation will support the return of hand and arm function and strengthen the cortical representations of targeted muscles. The investigators will assess this through TMS mapping and clinical measures of hand and arm function.

Description:

The recovery of hand and arm function is of critical importance for decreasing long-term care costs and increasing quality of life for individuals with tetraplegia due to spinal cord injury (SCI). A subset of these individuals, with injuries in the mid to low cervical spinal cord, are candidates for nerve transfer surgery. Nerve transfer surgery restores function after SCI through coaptation of redundant, intact donor nerves to recipient nerves arising at or below the level of SCI. The use of nerve transfer after SCI is relatively novel and many patients exhibit a remarkable recovery of hand and arm motor function in the months that follow, however others show a much more limited recovery. The extent of recovery is likely limited, in part, by variability in rehabilitation and the ability of the motor cortex to incorporate the new peripheral circuitry resulting from this surgical procedure. There is a critical need to determine the response of cortical motor networks to nerve transfer and the role that rehabilitation plays in supporting cortical plasticity and motor recovery. If this need is not met, incomplete recovery from this state-of-the-art surgical intervention will persist and the potential application to a wider patient population will not be realized. The investigators will test the central hypothesis that nerve transfer surgery after cervical SCI creates a novel cortical motor network, which can support the return of dexterous hand/forelimb function through rehabilitation-dependent remodeling. The hypothesis has been based upon 1) previous work in an animal model showing that rehabilitation reshapes cortical motor maps, 2) the pioneering work of a handful of clinicians, including the study collaborator, Justin Brown, that have applied nerve transfer to bypass spinal levels affected by injury, and 3) recent work using transcranial magnetic stimulation (TMS) in human SCI to map the cortical representation of arm muscles in the zone of partial preservation, and the ability to improve hand-arm function through intensive robotic training in chronically impaired subjects. The use of TMS to map cortical motor networks will allow the investigators to measure the cortical reorganization resulting from nerve transfer and determine the extent to which rehabilitation can engage this alternative cortical motor network. The rationale for the proposed studies is that a determination of the mechanisms that support rehabilitation-mediated recovery after nerve transfer will be required for optimizing and refining current clinical practice.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 12
• Est. completion date: December 31, 2026
• Est. primary completion date: December 31, 2025
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 50 Years

Eligibility

Inclusion Criteria:

• Tetraplegia (cervical lesion) with some degree of motor dysfunction in the hand
• Motor incomplete or complete lesion (measured by the ASIA Impairment Scale, A, B, C, D).
• Chronic lesion (at least 6months after the injury)
• Demonstrate stability of motor examination for at least six months.
• Retain intact innervation within paralyzed target muscles (axon recipient) as determined by electrodiagnostics.
• Have muscles innervated by the nerves to be used for the transfers (axon donors) of MRC grade 4/5 or greater and sufficient innervation as determined by electrodiagnostics.
• Have access to an at home caregiver who can assist with customary postsurgical physical therapy.
• Ability to give informed consent and understand the tasks involved.

Exclusion Criteria:

• Presence of potential risk factor for brain stimulation: history of seizures, presence of surgically implanted foreign bodies such as a pacemaker, metal plate in the skull, and metal inside the skull.
• History of head trauma and/or cognitive deficit
• Medically unstable
• Contraindicated for nerve transfer surgery.

Related Conditions & MeSH terms

• Cervical Spinal Cord Injury
• Quadriplegia
• Spinal Cord Injuries
• Tetraplegia
• Wounds and Injuries

Intervention

Device:
• Upper limb robotic training
Subjects will remain seated in their own wheelchair in front of the InMotion Hand™ Robot (Interactive Motion Technologies, Massachusetts, MA, Figure 6) facing a video screen. The arm of the participants will be abducted, forearm supported, and hand grasping a cone shaped handle. Velcro straps will lightly hold the forearm and fingers secure. The InMotion Hand™ robot attaches to the InMotion Arm™ robots to provide 'assisted-as-needed'™ gross grasp and release motion and support for functional reach. In each session, patients perform a total of 1024 movement repetitions (Cortes et al., 2013). Patients will receive a total of 18 sessions (3x/week, 6 weeks) comprising one hour of interactive hand robotic training. The interactive robotic features involve visuomotor task, moving the robotic manipulandum according to targets on a computer screen mounted at eye level.

Procedure:
• Nerve transfer surgery
C5 injury; Teres minor branch of axillary nerve transferred to long head of triceps branch of radial nerve (RN); Brachialis branch of musculocutaneous nerve to anterior interosseous nerve (AIN); Supinator branch of RN to posterior interosseous nerve (PIN). C6 injury; Teres minor branch of axillary nerve to long head of triceps branch of RN; Extensor carpi radialis brevis (ECRB) branch of RN to AIN; Supinator branch of RN to PIN. C7 injury with preserved triceps, loss of grasp/release; Pronator teres branch of median nerve to AIN; Terminal branch of ECRB branch of RN to flexor pollicis longus branch of AIN; Supinator branch of RN transferred to PIN. C7 injury with preserved triceps/finger extension, loss of grasp; Pronator teres branch of median nerve to AIN; Terminal branch of ECRB branch of RN to flexor pollicis longus branch of AIN.

Locations

Country	Name	City	State
United States	Burke Neurological Institute	White Plains	New York

Sponsors (2)

Lead Sponsor	Collaborator
Burke Medical Research Institute	Massachusetts General Hospital

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in Box and Blocks test score	The Box and Blocks test measures how many blocks a person can grasp and transfer in one minute. A higher score is associated with better hand function.	1 year post surgery, immediately post training, minus baseline before surgery
Secondary	Upper extremity motor score (UEMS)	The Upper extremity motor score (UEMS) tests the clinical motor strength from 0 to 5 from each key muscle using the ASIA scale. This sum score ranges from 0 (paralyzed) to 25 (normal) in each limb.	1 year post surgery, immediately post training, minus baseline before surgery
Secondary	Spinal Cord Independence Measure (SCIM III)	The Spinal Cord Independence Measure (SCIM III) measures the ability of patients with SCI to perform everyday tasks according to their value for the patient. SCIM is used for quantitative functional outcome assessment following interventions designed to promote recovery from spinal cord injury and to increase functional achievement; and it covers 19 tasks in 16 categories (score range 0-100); all activities of daily living, grouped into four areas of function (subscales): Self-Care (scored 0-20), Respiration and Sphincter Management (0-40), Mobility in Room and Toilet (0-10), Mobility Indoors and Outdoors (0-30).	1 year post surgery, immediately post training, minus baseline before surgery
Secondary	Modified Ashworth Scale	The Modified Ashworth Scale (MAS) will be used to measure change in spasticity. The scale is a scale from 0 to 4 that measures muscle stiffness. A higher score is associated with greater spasticity.	1 year post surgery, immediately post training, minus baseline before surgery
Secondary	Single pulse transcranial magnetic stimulation	Changes in resting motor threshold (RMT), motor evoked potential (MEP) amplitude will be measured in each muscle of both arms using a MagStim X100 stimulator (MagStim) and a figure-8 coil. We will investigate the neurophysiological correlates of function, and the characteristics of participants who respond better to the training.	1 year post surgery, immediately post training, minus baseline before surgery