Clinical Trials Logo

Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT03104803
Other study ID # ULD 8100014-2
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date March 31, 2017
Est. completion date October 30, 2018

Study information

Verified date September 2019
Source Helsinki University Central Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The investigators have recently shown in incomplete SCI patients that long-term paired associative stimulation is capable of restoring voluntary control over some paralyzed muscles and enhancing motor output in the weak muscles (1). In this study, the investigators will administer long-term paired associative stimulation to patients with incomplete SCI of non-traumatic origin.


Recruitment information / eligibility

Status Completed
Enrollment 5
Est. completion date October 30, 2018
Est. primary completion date May 27, 2018
Accepts healthy volunteers No
Gender All
Age group 18 Years to 75 Years
Eligibility Inclusion Criteria:

- incomplete SCI of non-traumatic origin

Exclusion Criteria:

- epilepsy

- metal inclusion in the head area

- pacemaker

- hearing device

- high intracranial pressure

Study Design


Intervention

Device:
long-term paired associative stimulation
Paired associative stimulation (PAS) administered several times per week for 6 weeks to one hand. PAS comprises transcranial magnetic stimulation (eXimia magnetic stimulator, Nexstim Ltd, Helsinki, Finland) and peripheral nerve stimulation (given with Dantec Keypoint® electroneuromyography device (Natus Medical Incorporated, Pleasanton, CA, USA)).

Locations

Country Name City State
Finland BioMag laboratory Helsinki

Sponsors (3)

Lead Sponsor Collaborator
Helsinki University Central Hospital Helsinki University, Validia Rehabilitation Center

Country where clinical trial is conducted

Finland, 

References & Publications (1)

Tolmacheva A, Savolainen S, Kirveskari E, Branstack N, Mäkelä JP, Shulga A. Paired associative stimulation improves hand function after non-traumatic spinal cord injury: A case series. Clinical Neurophysiology Practice, 4: 178-183, 2019.

Outcome

Type Measure Description Time frame Safety issue
Primary Daniels and Worthingham's Muscle Testing each hand muscle is evaluated on 0-5 scale 2 days after the last stimulation session
Primary Daniels and Worthingham's Muscle Testing each hand muscle is evaluated on 0-5 scale 1 month after the last stimulation session
See also
  Status Clinical Trial Phase
Active, not recruiting NCT06321172 - Muscle and Bone Changes After 6 Months of FES Cycling N/A
Completed NCT03457714 - Guided Internet Delivered Cognitive-Behaviour Therapy for Persons With Spinal Cord Injury: A Feasibility Trial
Recruiting NCT05484557 - Prevention of Thromboembolism Using Apixaban vs Enoxaparin Following Spinal Cord Injury N/A
Suspended NCT05542238 - The Effect of Acute Exercise on Cardiac Autonomic, Cerebrovascular, and Cognitive Function in Spinal Cord Injury N/A
Recruiting NCT05503316 - The Roll of Balance Confidence in Gait Rehabilitation in Persons With a Lesion of the Central Nervous System N/A
Not yet recruiting NCT05506657 - Early Intervention to Promote Return to Work for People With Spinal Cord Injury N/A
Recruiting NCT03680872 - Restoring Motor and Sensory Hand Function in Tetraplegia Using a Neural Bypass System N/A
Recruiting NCT04105114 - Transformation of Paralysis to Stepping Early Phase 1
Completed NCT04221373 - Exoskeletal-Assisted Walking in SCI Acute Inpatient Rehabilitation N/A
Completed NCT00116337 - Spinal Cord Stimulation to Restore Cough N/A
Completed NCT03898700 - Coaching for Caregivers of Children With Spinal Cord Injury N/A
Recruiting NCT04883463 - Neuromodulation to Improve Respiratory Function in Cervical Spinal Cord Injury N/A
Active, not recruiting NCT04881565 - Losing Balance to Prevent Falls After Spinal Cord Injury (RBT+FES) N/A
Completed NCT04864262 - Photovoice for Spinal Cord Injury to Prevent Falls N/A
Recruiting NCT04007380 - Psychosocial, Cognitive, and Behavioral Consequences of Sleep-disordered Breathing After SCI N/A
Active, not recruiting NCT04544761 - Resilience in Persons Following Spinal Cord Injury
Terminated NCT03170557 - Randomized Comparative Trial for Persistent Pain in Spinal Cord Injury: Acupuncture vs Aspecific Needle Skin Stimulation N/A
Completed NCT03220451 - Use of Adhesive Elastic Taping for the Therapy of Medium/Severe Pressure Ulcers in Spinal Cord Injured Patients N/A
Recruiting NCT04811235 - Optical Monitoring With Near-Infrared Spectroscopy for Spinal Cord Injury Trial N/A
Recruiting NCT04736849 - Epidural and Dorsal Root Stimulation in Humans With Spinal Cord Injury N/A