Spinal Cord Injuries Clinical Trial
Official title:
Efficacy Difference Between Rehabilitation Therapy and Umbilical Cord Derived Mesenchymal Stem Cells Transplantation in Patients With Acute or Chronic Spinal Cord Injury in China
The morbidity of spinal cord injury (SCI) is increasing significantly in China. The methods
to treat SCI patients in sequela stage update are poor. Though traditional rehabilitation
therapy is the routine method to treat SCI in sequela stage, its effect to improve the
neurological disorders of these patients, such as the dysfunction of sense, motor, autologous
adjustment of blood pressure control of urination and defecation, perspiration , etc. is
unsatisfying. Rehabilitation Therapy can prevent the process of muscle atrophy and joint
stiffness. However, it can not repair the damaged nerve function. Studies show that
mesenchymal stem cell transplantation can remarkably improve the neurological function of SCI
in animals without any severe side effect.
In this study, the investigators use mesenchymal stem cells derived from umbilical cord to
treat 40 SCI patients (20 cases in early stage and 20 cases in sequela stage). The
investigators also follow-up ten patients who only receive rehabilitation and another ten
outpatients who accept neither stem cell therapy nor rehabilitation. On this basis, the
investigators can compare the efficacy of these two treatments.
Patients enrolled in this study need to finish our whole follow-up survey, which is carried out by clinical doctors and epidemiologist. ;
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