Prevention of Post Operative Bone Loss in Children

Status Completed

Clinical Trial Summary

Hypothesis: one-dose pamidronate will prevent post-operative bone loss in children at risk for low bone density Plan: children with chronic disease such as CP, spina bifida, etc. will be recruited pre operatively and studied with DXA scan. After surgery, children will be randomized to receive either pamidronate or saline. Repeat DXA scan will determine bone lost after end of immobilization or nonweightbearing.

Clinical Trial Description

Children at risk for post operative bone loss will be studied with preoperative DXA scan of spine and distal femora Preoperative screening with standard labs electrolytes, Ca++, PO4, creatinine, Vit D Following surgery of hip(s) or lower extremities, randomization into treatment with low dose IV pamidronate (one dose) v placebo group Repeat DXA scan after end of immobilization or non-weightbearing ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00655681
Study type	Interventional
Source	University of New Mexico
Contact
Status	Completed
Phase	N/A
Start date	September 2007
Completion date	August 2011

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