A Prospective Study of Spasticity in Individuals With Multiple Sclerosis

Status Active, not recruiting

Clinical Trial Summary

This study is expected to contribute to the body of knowledge on the benefits of individuals with MS taking glatiramer acetate (Copaxone®). If patients have less spasticity when taking glatiramer acetate (Copaxone®), they may be more likely to have an improved quality of life.

The hypotheses for this study are:

1. Study participants who transition from interferon therapy to glatiramer acetate (Copaxone®) for a six month period will have a decrease in spasticity.

2. Study participants who transition from interferon therapy to glatiramer acetate (Copaxone®) for a six month period will have a change in perceptions of the impact of spasticity on their lives.

Clinical Trial Description

The purpose of this study is to determine if there is a change in spasticity and perceptions of the impact of spasticity in individuals with multiple sclerosis who transition from interferon to glatiramer acetate (Copaxone®).•

- Potential participants meeting the criteria will be identified by Shared Solutions and informed of the study. Interested individuals will contact the investigator either by email or telephone. Enrollment will continue until there are 110 participants starting glatiramer acetate (Copaxone®).

- Potential participants will be informed of the details of the study, eligibility will be confirmed, and participant's questions answered.

- The two study instruments and the sociodemographic questionnaire will be emailed or mailed via UPS along with an information letter. May be returned either via email, fax or UPS mail.

- At month 6 for each participant, the study instruments and sociodemographic questionnaire will be sent a second time and returned to the investigator. ;

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01111435
Study type	Observational
Source	Fraser, Cira, Ph.D., RN, ACNS-BC
Contact
Status	Active, not recruiting
Phase	N/A
Start date	April 2010
Completion date	December 2012

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT06150729` - Study of Intramuscular Injections of OnabotulinumtoxinA to Assess Change in Disease Activity in Pediatric Participants With Spasticity Associated With Cerebral Palsy
Completed	`NCT02400619` - Shockwaves Therapy and Botulinum Toxin for the Treatment of Spasticity in Patients With Cerebral Palsy. A Cross Over RCT	Phase 1
Completed	`NCT01945684` - A Randomized, Double Blind, Multi-center, Active Drug Controlled, Phase III Clinical Trial to Compare the Safety and Efficacy of DWP450 Versus Botox® in Treatment of Post Stroke Upper Limb Spasticity	Phase 3
Completed	`NCT02261142` - Efficacy and Cost-effectiveness of Spasticity Treatment With Multifocal TENS	N/A
Completed	`NCT01444794` - Adult Subjects Suffering From Lower Limb Spasticity Following Stroke
Terminated	`NCT02877836` - Functional MRI and DTI in the Preoperative Assessment of Dystonia	N/A
Completed	`NCT02334683` - Compare Two Guidance Techniques for Botulinum Toxin Injections for the Treatment of Limb Spasticity and Focal Dystonia	N/A
Completed	`NCT02170779` - Developing and Testing a Comprehensive MS Spasticity Management Program	Phase 2
Recruiting	`NCT05674604` - Cryoneurolysis for Knee and Shoulder Pain in an Inpatient Setting
Not yet recruiting	`NCT05926596` - Leg Stretching Using an Exoskeleton on Demand for People With Spasticity	N/A
Terminated	`NCT01712087` - Long-term Surveillance of the MedStream Programmable Infusion System
Completed	`NCT03906305` - Dry Needling and Bobath Treatment Clinical Effects Focused on Stroke Patients	N/A
Completed	`NCT03302741` - Imaging of 3D Innervation Zone Distribution in Spastic Muscles From High-density Surface EMG Recordings	Phase 4
Completed	`NCT02291159` - Effects of DNHS Technique in the Treatment of Upper Limb Spasticity and Function in Stroke	N/A
Completed	`NCT01743651` - Efficacy Study of Arbaclofen to Treat Spasticity in Multiple Sclerosis	Phase 3
Completed	`NCT01523210` - DTI Study of the Influence of Physiotherapy on Distribution of BoNT in Spastic Muscle	N/A
Completed	`NCT02073513` - Kinesiotaping the Hand in Cerebral Palsy	N/A
Completed	`NCT00607542` - Oral Baclofen Pharmacokinetics and Pharmacodynamics in Children With Spasticity	Phase 1/Phase 2
Completed	`NCT00702468` - Evaluate the Maintenance of Effect After Long-term Treatment With Sativex® in Subjects With Symptoms of Spasticity Due to Multiple Sclerosis	Phase 3
Active, not recruiting	`NCT04815967` - Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Upper Limb Spasticity	Phase 2/Phase 3