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Spastic Paraplegia, Hereditary clinical trials

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NCT ID: NCT05767268 Completed - Cerebral Palsy Clinical Trials

Assessment of the Psychophysical State During Rehabilitation Treatment With Lokomat

Start date: February 2, 2022
Phase:
Study type: Observational

The use of robotic technologies in rehabilitation is an increasingly widespread practice in the health sector: the Lokomat is a medical device intended for walking rehabilitation, consisting of an exoskeleton, a treadmill and a harness that supports the body weight and acts as a safety tool This technology is useful in the rehabilitation of pathologies such as prenatal stroke, brain injury, paraplegia, multiple sclerosis and other motor, orthopedic and neurological problems. During these treatments, the psychological / emotional component of the patient is not properly considered and the success of the treatment remains focused on the motor-rehabilitation level. The management of subjective-experiential aspects remains in the hand of clinical figures (primarily physiotherapists) who have no tools for objective assessment other than their sensitivity. However, considering the experience is fundamental for the success of the therapy: this happens especially in the pediatric field, where clinical results improve significantly when children start therapy with a relaxed and positive mental state. The aim of this project is to investigate the rehabilitation experience of patients who perform gait rehabilitation by menas of the Lokomat system, considering the relationship between physiological parameters and moods. Therefore, the main goal is to monitor the patient's psychophysical condition before, during and after the rehabilitation activity, during the different sessions. This will allow describing, with qualitative and quantitative data, the user experience of the patient who undergoes a therapeutic treatment with the Lokomat.

NCT ID: NCT05613114 Completed - Clinical trials for Hereditary Spastic Paraplegia

Effect of Dalfampridine in Patients With Hereditary Spastic Paraplegia

Start date: August 3, 2020
Phase: N/A
Study type: Interventional

There are limited but encouraging results supporting the use of dalfampridine in patients with hereditary spastic paraplegia. The investigators aimed to investigate the effects of dalfampridine on walking speed, muscle length, spasticity, functional strength, and functional mobility in patients with hereditary spastic paraplegia. In this triple-blinded, randomized, placebo-controlled trial, 4 patients with hereditary spastic paraplegia received dalfampridine (10 mg twice daily) plus physiotherapy (2 times per week), and 4 patients received placebo plus physiotherapy for a total duration of 8 weeks. The assessor and treating physiotherapists, and patients were masked to the group allocation. The primary outcome was Timed 25-foot Walk Test at the end of the 8-week treatment. The secondary outcome measures were functional mobility, functional muscle strength, muscle length, and spasticity.

NCT ID: NCT05373082 Completed - Clinical trials for Hereditary Spastic Paraplegia

Identification of Modifying Factors in Hereditary Spastic Paraplegia

MODIFSPA2
Start date: October 4, 2022
Phase:
Study type: Observational

A first questionnaire - MODIFSPA conducted in 2014 - identified several environmental factors influencing spasticity in HSP: cold, fatigue, and especially physical activity. In order to improve the care of patients with HSP, The investigator team are looking to deepen the knowledge on physical exercises relieving spasticity as well as to better know the frequency of symptoms requiring additional medical care: fatigue and vesico-sphincter disorders. A new questionnaire was therefore created to collect additional information to optimize the care of patients with HSP.

NCT ID: NCT04912609 Completed - Clinical trials for Hereditary Spastic Paraplegia

Trehalose Administration in Subjects With Spastic Paraplegia 11 (3AL-SPG11)

3AL-SPG11
Start date: June 30, 2021
Phase:
Study type: Observational

Hereditary spastic paraparesis type 11 (SPG11) is caused by mutations in the SPG11 gene that produces spatacsin, a protein involved in lysosomal function.

NCT ID: NCT04180098 Completed - Clinical trials for Hereditary Spastic Paraplegia

Improving Gait Adaptability in Hereditary Spastic Paraplegia

Move-HSP
Start date: December 1, 2019
Phase: N/A
Study type: Interventional

This study evaluates the effects of ten hours C-mill training on gait adaptability in participants with hereditary spastic paraplegia (HSP). Half of the participants start with five weeks of C-mill training (ten 1-hour sessions). The other participants are placed on a waiting list, which is followed by the same five weeks of C-mill training (ten 1-hour sessions). It is hypothesized that ten hours of context specific C-mill training is effective in improving gait adaptability in participants with pure HSP.

NCT ID: NCT03961906 Completed - Clinical trials for Hereditary Spastic Paraplegia

Physiotherapy in Hereditary Spastic Paraplegia

Start date: January 1, 2015
Phase: Phase 2
Study type: Interventional

Goal of this study is to develop and evaluate a physiotherapy concept that is focused on bilateral leg spasticity and aims to reduce spastic gait disturbance and to improve mobility in patients suffering from HSP.

NCT ID: NCT03627416 Completed - Clinical trials for Hereditary Spastic Paraplegia

Repetitive Transcranial Magnetic Stimulation as Therapy in Hereditary Spastic Paraplegia and Adrenomyeloneuropathy

Start date: January 9, 2017
Phase: N/A
Study type: Interventional

Hereditary spastic paraplegia (HSP) is the group of inherited disorders, characterized by progressive gait disturbance. There is no established therapy. Adrenoleukodystrophy (AMN) is an x-linked hereditary disease. One of its form, the adrenomyeloneuropathy has the same symptoms as HSP. Current therapeutic options for AMN are very limited. Repetitive Transcranial Magnetic Stimulation (rTMS) is a noninvasive method of modulation of brain plasticity. The purpose of this study is to compare the effectiveness of rTMS in improving the HSP- and AMN-related gait disturbance and other symptoms with sham stimulation. Intervention will include five daily sessions. In each session 1500 magnetic pulses will be administered to each of both primary motor areas for lower extremities. Assessment of gait and of strength and spasticity of lower extremities will be made before and after therapy, as well as two weeks later.

NCT ID: NCT03104088 Completed - Clinical trials for Cognitive Impairment

Studying Cognition in SPG4

Start date: May 10, 2017
Phase:
Study type: Observational

Comparing the cognitive levels of patients with SPG4 mutations to healthy controls.

NCT ID: NCT02852278 Completed - Clinical trials for Amyotrophic Lateral Sclerosis

A Patient Centric Motor Neuron Disease Activities of Daily Living Scale

Start date: December 2016
Phase:
Study type: Observational

The purpose of this study is to learn about rates of patient-reported disease progression in patients with motor neuron diseases (amyotrophic lateral sclerosis, progressive muscular atrophy, primary lateral sclerosis, hereditary spastic paraplegia) outside the clinical setting, and the patient-reported clinical characteristics that influence this rate of progression. All patients enrolled in CReATe Connect, a Rare Diseases Clinical Research Network (RDCRN) Contact Registry, will be invited via email to participate in this study.

NCT ID: NCT02604186 Completed - Clinical trials for Hereditary Spastic Paraplegia

Effects of Botulinum Toxin Injections in Patients With Hereditary Spastic Paraplegia

SPASTOX
Start date: March 9, 2016
Phase: Phase 2/Phase 3
Study type: Interventional

Hereditary spastic paraplegias constitute a heterogeneous group of diseases with the common predominant feature of spasticity of the lower limbs. The clinical picture is composed of difficulty walking, exaggerated deep reflexes, pathological reflexes such as the Babinski sign, sphincter disturbances and various degrees of weakness as well as sensory disturbances. Spasticity is the symptom that provoques greater incapacity. Although there have been recent advances in the genetic and pathogenic characterization of SPG there is scarcity of therapeutic options. The Botulinum Toxin (BTx) is a well established treatment for movement disorders such as cervical dystonia, blepharospasm, and arm spastic following stroke. Therefore, the investigators propose the execution of a randomized, double-blind, placebo-controlled, crossover study to evaluate the efficacy of the treatment with Btx over SPG patient's gait. The primary outcome measure will be gait velocity with the 10 meter walking test 8 weeks after injection. Each participant will be submitted to one injection session of Btx and one of placebo (consisting of sterile sodium chloride), each one separated by a period of 6 months. The primary and secondary outcomes will be evaluated by a blind investigator 8 weeks after each injection session.