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A Randomized Study of Autologous Umbilical Cord Blood Reinfusion in Children With Cerebral Palsy

Cerebral Palsy Clinical Trial

Official title:
Is Autologous Umbilical Cord Blood Reinfusion Beneficial in Children With Cerebral Palsy: A Randomized, Blinded, Placebo-Controlled, Crossover Study

Clinical Trial Summary

The purpose of this study is to determine the efficacy of a single intravenous infusion of autologous umbilical cord blood (UCB) for the treatment of pediatric patients with spastic cerebral palsy.

Clinical Trial Description

Cerebral palsy results from in utero or perinatal injury to the developing brain, often through stroke, hypoxic insult or hemorrhage. Currently available treatments for patients with cerebral palsy are supportive, but not curative. Umbilical cord blood (UCB) has been shown to lessen the clinical and radiographic impact of hypoxic brain injury and stroke in animal models. UCB also engrafts and differentiates in brain, facilitating neural cell repair, in animal models and human patients with inborn errors of metabolism undergoing allogeneic, unrelated donor UCB transplantation. We hypothesize that, in the setting of brain injury, infusion of autologous UCB will facilitate neural cell repair resulting in improved function in pediatric patients with cerebral palsy. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01147653
Study type Interventional
Source Duke University
Contact
Status Completed
Phase Phase 2
Start date June 2010
Completion date March 2016
View Details
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