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Solid Tumors, Adult clinical trials

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NCT ID: NCT06404528 Recruiting - Solid Tumors, Adult Clinical Trials

Low-dose Chemotherapy Under Hypoglycaemia for the Treatment of Relapsed Refractory Advanced Solid Tumours

Start date: September 4, 2023
Phase: N/A
Study type: Interventional

By controlling the patient's blood sugar, small doses of chemotherapy are used in a hypoglycemic state. Some necrotic tumor cells produced by chemotherapy can maintain their immunogenicity, further activate innate immunity, and produce very strong anticancer effects without the cytotoxic effects of chemotherapy.

NCT ID: NCT06088472 Recruiting - Solid Tumors, Adult Clinical Trials

TIL Injection for the Treatment of Metastatic or Recurrent Solid Tumors

Start date: April 21, 2021
Phase: Early Phase 1
Study type: Interventional

This is a multicenter, single-arm phase I clinical trial.The study process was divided into: screening period, sampling and production period, clear lung pretreatment period, treatment and observation period, and follow-up period.

NCT ID: NCT05887492 Recruiting - Breast Cancer Clinical Trials

Study of TNG260 and an Anti-PD Antibody in STK11 Mutated Solid Tumors

Start date: June 12, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

The goal of this interventional clinical trial is to learn about TNG260, a CoREST inhibitor, in combination with pembrolizumab in patients with advanced solid tumors with a known STK11 mutation. The main question[s] it aims to answer are: - the recommended dose for Phase 2 - to evaluate the safety and tolerability of the combination therapy - to determine the pharmacokinetics of TNG260 - to evaluate the initial antineoplastic activity Participants will receive study treatment until they experience an undesirable side effect, their disease progresses or until they withdraw consent.

NCT ID: NCT05861895 Recruiting - Solid Tumors, Adult Clinical Trials

A Clinical Study to Investigate the Safety, Tolerability, Pharmacokinetics, Immunogenicity and Preliminary Efficacy of HF158K1 in Participants With HER-2 Positive or HER-2 Low Expression Advanced Solid Tumors

Start date: December 12, 2023
Phase: Phase 1
Study type: Interventional

HF158K1 is an investigational liposome form of doxorubicin hydrochloride, an anthracycline topoisomerase inhibitor, encapsulated by lipid membranes containing TL01, a HER2-directed Trastuzumab Fab fragment conjugated lipid.

NCT ID: NCT05768139 Recruiting - Breast Cancer Clinical Trials

First-in-Human Study of STX-478 as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors

Start date: April 17, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

Study STX-478-101 is a multipart, open-label, phase 1/2 study evaluating the safety, tolerability, pharmacokinetics (PK), and preliminary antitumor activity of STX-478 in participants with advanced solid tumors with certain mutations. Part 1 will evaluate STX-478 as monotherapy in participants with advanced solid tumors and breast cancer; Part 2 will evaluate STX-478 therapy as combination therapy with fulvestrant in participants with breast cancer. Each study part will include a 28-day screening period, followed by treatment with STX-478 monotherapy or combination therapy.

NCT ID: NCT05747339 Not yet recruiting - Solid Tumors, Adult Clinical Trials

A Clinical Study on the Efficacy and Mechanism of Tumor Treatment Vaccine (TTV) for Recurrent and Refractory Advanced Solid Tumors

Start date: June 7, 2023
Phase: N/A
Study type: Interventional

This is a study of the clinical efficacy and mechanism study of tumor treatment vaccine (TTV, also known as Neo-BCV) in patients with recurrent and refractory advanced solid tumors.

NCT ID: NCT05698888 Terminated - Multiple Myeloma Clinical Trials

Study of VP301 in Patients With Multiple Myeloma, Lymphoma, or Solid Tumors

Start date: November 29, 2022
Phase: Phase 1
Study type: Interventional

This study will test the safety, tolerability, and pharmacokinetics of VP301 in patients with relapsed or refractory multiple myeloma, lymphoma, or solid tumors.

NCT ID: NCT05472220 Withdrawn - Clinical trials for Metastatic Malignant Solid Neoplasm

Alpelisib in Combination With Carboplatin in Patients With Solid Tumors and HPV-Positive Squamous Cell Carcinoma

Start date: November 1, 2022
Phase: Phase 1
Study type: Interventional

This phase I/II trial tests the safety, side effects, and best dose of alpelisib and whether alpelisib and carboplatin work to shrink tumors in patients with solid tumors or human papillomavirus (HPV) positive squamous cell carcinoma that has spread to nearby tissue or lymph nodes (locally advanced) or has spread to other places in the body (metastatic). Alpelisib belongs to a group of medicines called phosphatidylinositol 3-kinase (PI3K) inhibitors. This means alpelisib blocks the activity of the PI3K protein. The PI3K pathway is well known to be involved in tumor cell multiplication and survival. Blocking PI3K may reduce the ability of certain cancers to grow. Carboplatin is an anticancer drug or chemotherapy drug that binds to DNA causing damage that prevents the DNA from replicating, which prevents the cells itself from reproducing. Giving alpelisib and carboplatin may help control the disease in patients with solid tumors and HPV positive squamous cell carcinoma.

NCT ID: NCT05430373 Recruiting - Solid Tumors, Adult Clinical Trials

GT101 Injection for the Treatment of Metastatic or Recurrent Solid Tumors

Start date: May 23, 2022
Phase: Phase 1
Study type: Interventional

This is a multicenter, single-arm phase I clinical trial.The study process was divided into: screening period, sampling and production period, clear lung pretreatment period, treatment and observation period, and follow-up period. The study is designed to enroll 20-31 subjects, with 14-20 subjects expected to be evaluable, in an "autologous tumor-infiltrating lymphocyte therapy" regimen that includes: 1. Clear lymphatic pretreatment (FC regimen: cyclophosphamide + fludarabine). 2. GT101 infusion. 3. post-infusion treatment (interleukin-2 intravenous push).

NCT ID: NCT05354323 Recruiting - Solid Tumors, Adult Clinical Trials

NECVAX-NEO1 in Addition to Checkpoint Inhibitor in Patients With Solid Tumors

Start date: May 5, 2022
Phase: Phase 1
Study type: Interventional

NECVAX-NEO1 in addition to anti-PD-1 or anti-PD-L1 monoclonal antibody checkpoint inhibitor monotherapy in n=15 patients with solid tumors