A Phase 1/2 Study of PBI-410 in Advanced Solid Tumors

Status Recruiting

Clinical Trial Summary

This is a Phase 1/2, first in human (FIH), open-label, multicenter study of PBI-410 in participants with previously treated, advanced solid tumors.

Clinical Trial Description

This is a Phase 1/2, first in human (FIH), open-label, multicenter study of PBI-410, a Trop-2 directed antibody-drug conjugate (ADC), in participants with previously treated, advanced solid tumors. The study comprises 2 parts: a Phase 1 Dose Escalation and a Phase 2 Dose Expansion. The Phase 1 will investigate the safety and tolerability of PBI-410 and identify one or more recommended doses for expansion (RDEs) and the maximum-tolerated dose (MTD) (if one exists). Phase 2 will investigate the preliminary efficacy of PBI-410 in signal-finding expansion cohorts. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06384807
Study type	Interventional
Source	Biohaven Pharmaceuticals, Inc.
Contact	Chief Medical Officer
Phone	203-404-0410
Email	clinicaltrials@biohavenpharma.com
Status	Recruiting
Phase	Phase 1/Phase 2
Start date	April 22, 2024
Completion date	February 2028

View Details

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