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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT06145802
Other study ID # GRIT-CD-CHN-316-002
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date March 9, 2023
Est. completion date March 9, 2026

Study information

Verified date November 2023
Source Grit Biotechnology
Contact Zhongping Cheng, PHD
Phone +86 13816686812
Email mdcheng18@263.net
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

This study is a single-arm, open clinical trial.This trial consists of two phases, dose-escalation and expansion, and the study process is divided into: a screening period, a sampling and production period, a lung-clearing pretreatment period, a treatment and observation period, and a follow-up period.


Recruitment information / eligibility

Status Recruiting
Enrollment 36
Est. completion date March 9, 2026
Est. primary completion date March 9, 2026
Accepts healthy volunteers No
Gender All
Age group 18 Years to 70 Years
Eligibility Inclusion Criteria: - 1. The Patients (or legally authorized representative) Patients (or legally authorized representative) must have the ability to understand the requirements of the study, have provided written informed consent as evidenced by signature on an informed consent form (ICF) approved by an Institutional Review Board/Independent Ethics Committee (IRB/IEC), must have the ability to understand the requirements of the study; - 2.Must have a confirmed diagnosis of malignancy of their receptive histologies or cytologies: unresectable recurrent or metastatic solid tumor; - 3.At least one resectable lesion (preferably superficial metastatic lymph nodes) that has not been treated with radiation and has not received other local therapies. The separated tissues =1.0cm^3 (either of single lesion origin or multiple lesions combined) for the preparation of autologous tumor-infiltrating lymphocytes. Minimally invasive treatment where possible; Exclusion Criteria: - 1. Subjects with =3 untreated CNS metastases at screening (If the subject has =3 CNS metastases with a maximum diameter of <1cm, and there is no peritumor edema on brain imaging (MRI or CT).no evidence of progressive CNS disease on brain imaging at least 3 months after treatment, then subjects will be included.); - 2.The patient who has any active autoimmune disease, history of autoimmune disease, need for systemic steroid hormones or a condition requiring immunosuppressive drug therapy (>10 mg/day of prednisone or equivalent hormone); - 3. Arterial/venous thrombotic events within 3 months prior to enrollment, such as: cerebrovascular accident, deep vein thrombosis and pulmonary embolism occurring - 4. Patients who have refractory or intractable epilepsy, poorly controlled hydrothorax, hydrops abdominis,pericardial effusion, active gastrointestinal bleeding or IL-2 contraindications; - 5. Participate in other clinical trials within 4 weeks prior to the first dose of this study, or planning to participate in this study and other clinical trials at the same - 6. Patients who have received allogeneic bone marrow transplantation or an organ allograft; - 7.Patients who have a history of hypersensitivity to any component or excipient of study drugs: autologous tumor infiltrating lymphocytes, cyclophosphamide, fludarabine, IL-2, dimethyl sulfoxide (DMSO), human serum albumin (HSA), dextran-40 and antibiotics (beta lactam antibiotics, gentamicin);

Study Design


Related Conditions & MeSH terms


Intervention

Biological:
GT316
Autologous Tumor Infiltrating Lymphocyte Injection

Locations

Country Name City State
China Shanghai Tenth People's Hospital Shanghai Shanghai

Sponsors (1)

Lead Sponsor Collaborator
Grit Biotechnology

Country where clinical trial is conducted

China, 

Outcome

Type Measure Description Time frame Safety issue
Primary Safety Profile Measured by Grade =3 TRAEs Safety Profile Measured by Grade =3 TRAEs by CTCAE 5.0 3 years
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