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Phase 1/2 Study of TU2218 Alone and in Combination With Checkpoint Inhibitors in Patients With Advanced Solid Tumors

Advanced Solid Tumor Clinical Trial

Official title:
A Phase 1/2 Study to Assess Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of TU2218, an Oral TGFβR Inhibitor, Administered Alone and in Combination With Pembrolizumab in Patients With Advanced Solid Tumors

Clinical Trial Summary

This study consists of Part A for monotherapy and Part B for combination therapy to evaluate safety, tolerability, pharmacokinetics, and preliminary efficacy of TU2218 in patients with advanced solid tumors. The main purpose of Phase 1 is to determined the recommended Phase 2 dose (RP2D) of TU2218 and the main purpose of Phase 2 is to evaluate the antitumor activity of TU2218 at RP2D.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05204862
Study type Interventional
Source TiumBio Co., Ltd.
Contact TiumBio Global http://www.tiumbio.com/en/
Phone 82-31-600-1500
Email nce401_tu2218@tiumbio.com
Status Recruiting
Phase Phase 1/Phase 2
Start date December 2, 2021
Completion date September 30, 2027
View Details
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