A Study of ZN-c3 in Participants With Solid Tumors

Status Recruiting

Clinical Trial Summary

This is a Phase 1 open-label, multicenter study of ZN-c3 monotherapy which consists of Dose Escalation, a Food Effect Cohort, and Dose Expansion.

Clinical Trial Description

This study will evaluate the safety, tolerability, efficacy, pharmacokinetics (PK) and pharmacodynamics of ZN-c3. In Dose Escalation, the study will identify the Maximum Tolerated Dose (MTD) of ZN-c3 monotherapy in solid tumors. The Food Effect cohort sub-study will examine ZN-c3 PK after a single dose and determine the bioavailability of ZN-c3 under fed and fasted conditions. In Dose Expansion, single agent ZN-c3 will be evaluated at the RP2D in subjects with recurrent or persistent uterine serous carcinoma (USC) or subjects with locally advanced or metastatic solid tumor malignancies harboring biomarkers related to deoxyribonucleic acid (DNA) damage pathways. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04158336
Study type	Interventional
Source	K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc
Contact	Project Director
Phone	858-263-4333
Email	medicalaffairs@zentalis.com
Status	Recruiting
Phase	Phase 1
Start date	November 1, 2019
Completion date	August 2023

View Details

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