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Clinical Trial Summary

This study is to characterize the safety, tolerability, pharmacokinetics (PK), immunogenicity, pharmacodynamics (PD) and anti-tumor activity of AK112, a PD-1/VEGF bispecific antibody, as a single agent in adult subjects with advanced solid tumor malignancies. This trial is a two parts, phase I/II study. All patients are advanced solid tumor, Eastern Cooperative Oncology Group (ECOG) performance status 0-1. Part one is dose escalation phase,part two is dose expansion phase. The primary end point is safety. Secondary end points are objective response rate,progression-free survival and overall survival per RECIST1.1.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04597541
Study type Interventional
Source Akeso
Contact
Status Active, not recruiting
Phase Phase 1/Phase 2
Start date October 21, 2020
Completion date May 2023

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