Advanced Refractory Solid Tumors With TP53 Mutations Register Study

Status Enrolling by invitation

Clinical Trial Summary

The efficacy and safety of the PARP inhibitor in combination with the VEGFR inhibitor will be investigated in advanced refractory solid tumors patients with TP53 mutation .

Clinical Trial Description

TP53 is a well-known tumor suppressor gene. Multiple studies have demonstrated that TP53 mutations are poor prognostic factor in advanced solid tumor, the TP53 gene is frequently inactivated by mutation in a majority of human tumors. However, no effective TP53 -based therapy has been successfully translated into clinical cancer treatment. So, investigators intend to review and evaluate the efficacy and safety of the PARP inhibitor in combination with the VEGFR inhibitor for TP53 mutation in advanced refractory solid tumors patients from a real-world population. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03927599
Study type	Observational
Source	Tianjin Medical University Second Hospital
Contact
Status	Enrolling by invitation
Phase
Start date	August 1, 2018
Completion date	January 31, 2020

View Details

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