Perfusion-Induced Hyperthermia for Metastatic Carcinoma

Status Completed

Clinical Trial Summary

The purpose of this study is to gather information on how safe the hyperthermia treatment delivered via the Exatherm-TBH (the device that will heat your blood and deliver it back to you), added to the best supportive care is to patients who have advanced persistent or recurrent, unresectable Cancer.

Clinical Trial Description

One potential candidate for a new approach to advanced cancer therapy is hyperthermia because cancer cells are thermo-sensitive, with significantly reduced heat shock protein (HSP) expression. Moreover, hyperthermia (42°C) causes repression of genes involved in the cell cycle and cellular growth and proliferation. Upon exposure to hyperthermic conditions, HSP expression is increased in normal cells. However, when cancer cells are exposed to hyperthermia, they initially express significantly less HSPs than normal cells, which sensitizes them to hyperthermia. Mild hyperthermia (43°C for less than two hours) induces extensive double-stranded DNA fragmentation and, at a later time, apoptosis in murine thymocytes. In cells with irreparable levels of DNA damage, apoptosis is the means of elimination. ;

Study Design

Related Conditions & MeSH terms

Carcinoma
Carcinoma, Non-Small-Cell Lung
Fever
Lung Neoplasms
Metastatic Non-Small Cell Lung Carcinoma
Solid Tumor, Adult

Clinical Trial Details

NCT number	NCT02409108
Study type	Interventional
Source	University of Kentucky
Contact
Status	Completed
Phase	N/A
Start date	July 2015
Completion date	February 16, 2019

View Details

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