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Clinical Trial Summary

There is increasing evidence that combination therapy with nanoparticle albumin-bound paclitaxel (nab-paclitaxel) and programmed cell death protein 1 (PD-1) inhibitor is safe and efficacious in treating many types of malignant tumors. However, clinical data demonstrating the effect of this treatment combination for patients with metastatic soft tissue sarcoma are currently limited. In this open, single center, one- armed clinical study, enrolled patients will receive the following treatment: 300 mg/m2 of nab-paclitaxel (Hengrui Pharmaceutical, Lianyungang, China) and 200 mg of PD-1 inhibitor (camrelizumab; Hengrui Pharmaceutical, Lianyungang, China) via a 30-min intravenous infusion on day 1. The treatment was repeated every three weeks until progressive disease occurrence or unacceptable adverse events. The primary end point was progression-free survival at 4 months. Secondary objectives were objective response rate and safety.

Clinical Trial Description


Study Design

Related Conditions & MeSH terms

NCT number NCT05189483
Study type Interventional
Source Henan Cancer Hospital
Contact Jiaqiang Wang, Dr.
Phone +8618737187831
Email [email protected]
Status Recruiting
Phase Phase 2
Start date January 1, 2022
Completion date July 31, 2023

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