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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT04910126
Other study ID # ACTS
Secondary ID
Status Recruiting
Phase Phase 2
First received
Last updated
Start date November 12, 2020
Est. completion date November 12, 2023

Study information

Verified date May 2021
Source Wuhan Union Hospital, China
Contact Jing Chen, MD, PhD
Phone 0086-027-85872987
Email chenjingwh@hust.edu.cn
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

To evaluate the efficacy and safety of the combination of adriamycin and Camrelizumab in the first-line treatment of advanced soft tissue sarcoma


Recruitment information / eligibility

Status Recruiting
Enrollment 84
Est. completion date November 12, 2023
Est. primary completion date January 12, 2023
Accepts healthy volunteers No
Gender All
Age group 18 Years to 60 Years
Eligibility Inclusion Criteria: - 1) Patients with advanced soft tissue sarcoma (pathologically confirmed undifferentiated pleomorphic sarcoma/synovial sarcoma/leiomyosarcoma/liposarcoma) not suitable for surgery; 2) Aged = 18 years old, < 60 years old; 3) Eastern Cooperative Oncology Group (ECOG) performance status score of 0-1, amputees can be 0-2; 4) Expected survival > 6 months; 5) Adequate organ and bone marrow function, defined as follows: ? Blood routine (14 days before screening without blood transfusion, without G-CSF, without drug correction): neutrophil count (ANC) = 1.5 × 10^9/L; platelet count (PLT) = 100 × 10^9/L; hemoglobin (Hb) = 100 g/L; ? Blood biochemistry: serum creatinine (Cr) = 1.5 × upper limit of normal (ULN) or creatinine clearance = 60ml/min; total bilirubin (TBIL) = 1.5 × ULN; aspartate aminotransferase (AST) or alanine aminotransferase (ALT) level = 2.5 × ULN, The subjects with liver metastasis should be = 5 × ULN; ? Coagulation function: international normalized ratio (INR) = 1.5, prothrombin time (PT) and activated partial thromboplastin time (APTT) = 1.5 × ULN; ? Urinalysis: urine protein < 2 +; if urine protein = 2 +, the 24-hour urine protein quantification must be = 1g; ? thyroid stimulating hormone (TSH) = ULN and = LLN; if abnormal, T3 and T4 levels should be investigated, normal T3 and T4 levels can be included. 6) ECG is basically normal, no myocardial ischemia performance, no history of arrhythmia requiring drug intervention, echocardiography LVEF = 50%; 7) no autoimmune diseases; 8) can provide tissue samples for biological testing; 9) have measurable lesions according to RECIST1.1 criteria; 10)Agree and have signed informed consent, willing and able to comply with scheduled visits, study treatment, laboratory tests and other test procedures.^ Exclusion Criteria: - 1) Patients who have previously received anthracycline treatment; 2) Patients who have previously received immunotherapy such as anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CTLA4, etc.; 3) Patients who are known to be allergic to recombinant humanized anti-PD-1 monoclonal antibody drugs and their components; 4) Patients with New York Heart Association (NYHA) score of more than II heart disease (including grade II); 5) Patients with mental or neurological disorders or do not cooperate; 6) Patients who have received other anti-tumor therapy 4 weeks before enrollment, including but not limited to surgery, radiotherapy, chemotherapy, targeted therapy, immunotherapy, etc.; 7) Patients who have used immunosuppressive drugs within 14 days before enrollment. Does not include nasal spray and inhaled corticosteroids or physiological doses of systemic steroids (i.e., no more than 10 mg/day prednisolone or other corticosteroids at physiological doses of the same drug); 8) any active autoimmune disease or history of autoimmune disease (subjects with vitiligo or asthma that has been completely relieved in childhood and currently does not require medical intervention can be included), or known history of allogeneic organ transplantation or allogeneic hematopoietic stem cell transplantation. 9) Known allergy to the study drug or any of its excipients; or severe allergic reactions to other monoclonal antibodies; 10) Patients with central nervous system metastasis; 11) Patients with severe systemic infection (who need intravenous antibiotics, antifungal or antiviral drugs) within 4 weeks before enrollment, or body temperature = 38.0?; 12) Patients received live vaccination within 4 weeks before the start of treatment; 13) HIV infection, HCV antibody positive and HCV RNA higher than the lower limit of detection of the analytical method, HBsAg or HBcAb positive and HBV DNA positive (quantitative detection limit of 500 IU/ml); 14) History of active pulmonary tuberculosis; 15) Patients who had been diagnosed with any other malignant tumor within 3 years before enrollment, except for adequately treated basal cell or squamous cell skin cancer or cervical carcinoma in situ; 16) Pregnant women or lactating women, or patients who plan to become pregnant during the study period or within one year after the use of the study drug; 17) Patients who participating in the trial is not in their best interest (such as endangering their health) or will hinder the evaluation of the trial protocol.

Study Design


Related Conditions & MeSH terms


Intervention

Drug:
Camrelizumab
Camrelizumab 200mg q3w up to 2 years
Adriamycin
adriamycin 20mg/m2 d1-3 q3w maximum 6 cycles

Locations

Country Name City State
China Union Hospital,Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei

Sponsors (1)

Lead Sponsor Collaborator
Wuhan Union Hospital, China

Country where clinical trial is conducted

China, 

Outcome

Type Measure Description Time frame Safety issue
Primary PFS progression-free survival up to three years
Secondary OS overall survival up to three years
Secondary ORR Objective Response Rate(ORR) Objective Response Rate up to one year
Secondary DOR Duration of Response up to two years
Secondary AE treatment related adverse events, TRAEs up to three years
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