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Clinical Trial Summary

The purpose of this research study is to determine the safety and tolerability of talimogene laherparepvec when combined with radiation therapy. Approximately 46 people will take part in this study conducted by investigators at the University of Iowa.


Clinical Trial Description

This is a single-arm open-label phase Ib and phase II clinical study assessing the safety and relative efficacy of concurrent talimogene laherparepvec in combination with radiotherapy in patients with soft tissue sarcomas. Patients will be treated with neoadjuvant radiation and weekly intratumoral injections of talimogene laherparepvec. Weekly injections of talimogene laherparepvec will be continued until surgery. Surgery will be performed 4-6 weeks from the end of radiation therapy to allow for resolution of acute toxicities per current standard of care. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04599062
Study type Interventional
Source University of Iowa
Contact
Status Active, not recruiting
Phase Phase 1/Phase 2
Start date September 10, 2020
Completion date November 2024

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