Soft Tissue Sarcoma Adult Clinical Trial
Official title:
Blood and Tissue Extraction for Immunological Examinations During Neoadjuvant Therapy of Soft Tissue Sarcomas
"Blood and Tissue Extraction for Immunological Examinations During Neoadjuvant Therapy of Soft Tissue Sarcoma" is a prospective study with additional translational research using preoperative and postoperative tissue, blood sampling and advanced imaging.
Status | Recruiting |
Enrollment | 30 |
Est. completion date | July 21, 2031 |
Est. primary completion date | July 21, 2026 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Planned histological confirmation for especially high-risk soft tissue sarcoma via open Sampling - Indication for neoadjuvant multimodal therapy (radiation and locoregional Hyperthermia, optionally with simultaneous chemotherapy) - Planned resection of a department of the CWS - Age > 18 years - Ability to consent - Additionally for imaging study: Treatment on the combined MR hyperthermia device Exclusion Criteria: - Age < 18 years - Poor understanding (language etc.) - Lack of reconnaissance ability |
Country | Name | City | State |
---|---|---|---|
Germany | University Hospital Tuebingen | Tübingen | Baden-Württemberg |
Lead Sponsor | Collaborator |
---|---|
University Hospital Tuebingen |
Germany,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Description of the cellular immune status via flow-cytometrie from collected blood samples | Blood samples are taken on the days of simulation-CT, first and third week of the radiation therapy, as well as before surgery. | 5 years of recruitment, 5 years follow-up | |
Primary | Description of the cellular immune status on tissue samples ussing komplex immunohistochemie | Tissue samples are taken as incisional biopsie as well as in the tumor tissue after the surgery | 5 years of recruitment, 5 years follow-up | |
Primary | Measurement of the cellular free DNA from collected blood samples | Blood samples are taken on the days of simulation-CT, first and third week of the radiation therapy, as well as before surgery. | 5 years of recruitment, 5 years follow-up | |
Primary | Measurement of HMGB1 from collected blood samples | Blood samples are taken on the days of simulation-CT, first and third week of the radiation therapy, as well as before surgery. | 5 years of recruitment, 5 years follow-up | |
Primary | Evaluation of morphological tumor characteristics (size, diffusion) with weekly MRIs | Weekly MRIs during neoadjuvant radiation therapy | 5 years of recruitment, 5 years follow-up |
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