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Sodium Disorder clinical trials

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NCT ID: NCT05215938 Completed - Image, Body Clinical Trials

Evaluation of Intra Organ Sodium Levels by Magnetic Resonance Imaging

Start date: July 7, 2021
Phase:
Study type: Observational

The investigators aim to implement an innovative imaging tool for detection of sodium level changes in-vivo with a clinical magnetic resonance (MR) scanner system. Conventionally, MR imaging (MRI) is performed with the use of proton imaging. Nevertheless, detection of other nuclei such as sodium (23Na) are possible with dedicated radio frequency sequences and radio frequency antennas tuned to the lower radio frequency of sodium. Non-invasive detection of sodium level changes has great potential as a precursor of organ deficiency and possible organ failure. This project seeks to determine a robust method for detection and characterization of sodium levels with MRI. The sodium levels of the kidneys are known to change throughout the day. Therefore, an evaluation of the kidney circadian sodium level variation is performed. In the proposed project, the investigators will scan two groups divided into two separate studies: Healthy controls for optimization of imaging (n = 5, scanned twice) Healthy controls for comparison of circadian variation (n = 10, scanned triple on one day) Sodium MRI could greatly improve the understanding and diagnostic capabilities of several medical conditions. If successful, the proposed project will serve as the groundwork for future clinical studies.

NCT ID: NCT04564508 Not yet recruiting - Sodium Disorder Clinical Trials

Sodium Status in Septic Patients and Its Relation to Prognosis an Hospital Stay

Start date: January 1, 2021
Phase:
Study type: Observational

The aim of the present study is to identify the prevalence and prognostic impact of sodium imbalance on sepsis and septic shock patients

NCT ID: NCT04116034 Completed - Heart Failure Clinical Trials

Alfapump Direct Sodium Removal (DSR) Feasibility Study

RED DESERT
Start date: December 26, 2019
Phase: N/A
Study type: Interventional

First in Human feasibility and sfafety study of the alfapump DSR system in the treatment of Heart failure subects resistant to diuretic therapy. Up to 10 subjects will be enrolled in up to 3 centres in Belgium and Georgia and will be iplanted with the alfapump DSR system. Subjects will undergo DSR titration during a 2 week hospitalisation period, and will continue titrated DSR therapy as outpatients for 4 more weeks.

NCT ID: NCT04043598 Recruiting - Critical Illness Clinical Trials

Crystalloid Fluid Choice and Neurological Outcome in Patients After Subarachnoid Haemorrhage

CRYSTALLBrain
Start date: May 24, 2022
Phase: N/A
Study type: Interventional

Patients with subarachnoid hemorrhage are prone to suffer from dysnatriemia. Evidence shows that hyponatriemia is associated with increased incidence of vasospasm, brain swelling and mortality in these patients. Patients with subarachnoid hemorrhage often require large amounts of iv fluids in order to maintain euvolemia and support cardiocirculatory function. Prior evidence shows that the type of infusion fluid significantly influences blood sodium content. Hence, this study evaluated whether the sodium content of the infusion solution impacts mortality and morbidity in patients with subarachnoid hemorrhage.

NCT ID: NCT03080831 Completed - Fluid Overload Clinical Trials

TOnicity of Perioperative Maintenance SoluTions

TOPMAST-1
Start date: March 9, 2017
Phase: Phase 4
Study type: Interventional

Prospective randomized double blind phase IV trial studying the efficacy and safety of the tonicity of two different perioperative maintenance solutions: an isotonic solution containing NaCl 0.9 in glucose 5% with an added 40 mmol/L of potassium or a commercially available premixed solution (Glucion 5%) containing a.o. 54 mmol/L of sodium and 26 mmol/L of potassium. Both solutions are administered at 27 mL/kg of ideal body weight, as recommended by current guidelines (NICE 174) and both solutions are widely used in daily clinical practice. The primary hypothesis is that isotonic maintenance solutions lead to more fluid retention than hypotonic fluids. Metabolism of both solutions is assessed by sequential analysis of urine and serum and clinical parameters.