Clinical and Radiographic Evaluation of Advanced Platelet Rich Fibrin in the Preservation of Alveolar Ridge Following Atraumatic Tooth Extraction

Socket Preservation Clinical Trial

Official title:

Clinical and Radiographic Evaluation of Advanced Platelet Rich Fibrin in the Preservation of Alveolar Ridge Following Atraumatic Tooth Extraction: A Randomized Clinical Trial

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT04197895
• Other study ID #: nana2019
• Status: Not yet recruiting
• Phase: N/A
• Start date: January 1, 2020
• Est. completion date: December 20, 2020

Study information

• Verified date: December 2019
• Source: Cairo University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

compare the effect of application of A-PRF in socket preservation after atraumatic tooth extraction and natural healing regarding to bone remodeling . Null hypotheis, after atraumatic extraction, socket with advanced PRF has no difference with socket with blood clot in primary outcome

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 36
• Est. completion date: December 20, 2020
• Est. primary completion date: August 10, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• The inclusion criteria are as follow :

• patients with an unremarkable medical history

• subjects with at least one site bordered by minimum of one tooth.

• Nonsmoker

• Teeth with root fracture, teeth with failed endodontic therapy or advanced caries

• Intact extraction socket with no dehiscence or fenestration.

• The buccolingual thickness of the buccal plate of bone in surgical area is 1 mm or more

Exclusion Criteria:

• Patients with systemic diseases.

• Patients with presence or history of osteonecrosis of the jaws, with use of bisphosphonates, exposure to head and neck radiation, chemotherapy.

• patients with large distinct pre-apical pathology

Related Conditions & MeSH terms

• Socket Preservation

Intervention

Procedure:
• Socket preservation with APRF
Socket preservation with APRF , A-PRF membranes were implanted into the extraction socket following tooth extraction. One entire A-PRF membrane would be placed at the base of the extraction socket and another A-PRF membrane will cover the extraction site then suturing will be done .Venous blood will be collected via venipuncture of the forearm with a butterfly needle into at least 10 mL sterile glass vacuum tube. The blood sample will be immediately centrifuged at 1,300 rpm (200 x g) for 8 minutes
• natural healing
after atraumatic extraction , the socket will be left for natural healing after suturing

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Nahed Gamal Saleh Abdelaal

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	mesial and distal height of extraction site	digital radiograph	2 months
Secondary	soft tissue thickness	will be evaluated by endo file with rubber stopper and digital caliper	2 months