Clinical Trial Details
— Status: Completed
Administrative data
NCT number |
NCT05142956 |
Other study ID # |
soonlin0001 |
Secondary ID |
|
Status |
Completed |
Phase |
|
First received |
|
Last updated |
|
Start date |
October 1, 2021 |
Est. completion date |
December 2, 2021 |
Study information
Verified date |
December 2021 |
Source |
Taipei Medical University Hospital |
Contact |
n/a |
Is FDA regulated |
No |
Health authority |
|
Study type |
Observational
|
Clinical Trial Summary
Cigarette smoking is associated with surgical complications, including wound healing and
surgical site infection. However, the association between smoking status and postoperative
wound complications is not completely understood. Our objective is to investigate the effect
of smoking on postoperative wound complications for major surgeries.
Description:
Smoking at the time of surgery is recognized as a risk factor for cardiovascular,
respiratory, and wound-related perioperative complications. Wound-related complications can
prolong hospital stays, increase hospital resource utilization, and pose an obvious threat to
patient recovery. A brief statement on perioperative smoking cessation about smoking
impacting wound healing was published by the American Society of Anesthesiologists' Task
Force on Smoking Cessation. Recently, a consensus statement on perioperative smoking
cessation by Society for Perioperative Assessment and Quality Improvement (SPAQI) mentioned
that smoking cessation should be done as soon as practicable with surgical scheduling. More
extended abstinence is associated with lower rates of wound healing complications.
Several studies have described smoking harms wound healing in specific operations, such as
plastic surgery, breast surgery, gastrointestinal surgery, and hip surgery. They found
surgical site infection and wound delayed healing more frequently in smokers. But in a few
small studies and some surgery, conflicting results were found. Besides, risk factors
associated with wound complications include infection, smoking, aging, malnutrition,
immobilization, diabetes, vascular disease, and immunosuppressive therapy.
This study aims to determine the impact of smoking on wound complications for all kinds of
major surgeries. To clarify the risks, our study uses the updated National Surgical Quality
Improvement Program (NSQIP) database to find if patients who were active smokers are more
likely to have wound-related complications postoperatively. We hypothesized that the active
smoking population will have increased infectious complications and wound dehiscence compared
with the nonsmoking population.