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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT05142956
Other study ID # soonlin0001
Secondary ID
Status Completed
Phase
First received
Last updated
Start date October 1, 2021
Est. completion date December 2, 2021

Study information

Verified date December 2021
Source Taipei Medical University Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Cigarette smoking is associated with surgical complications, including wound healing and surgical site infection. However, the association between smoking status and postoperative wound complications is not completely understood. Our objective is to investigate the effect of smoking on postoperative wound complications for major surgeries.


Description:

Smoking at the time of surgery is recognized as a risk factor for cardiovascular, respiratory, and wound-related perioperative complications. Wound-related complications can prolong hospital stays, increase hospital resource utilization, and pose an obvious threat to patient recovery. A brief statement on perioperative smoking cessation about smoking impacting wound healing was published by the American Society of Anesthesiologists' Task Force on Smoking Cessation. Recently, a consensus statement on perioperative smoking cessation by Society for Perioperative Assessment and Quality Improvement (SPAQI) mentioned that smoking cessation should be done as soon as practicable with surgical scheduling. More extended abstinence is associated with lower rates of wound healing complications. Several studies have described smoking harms wound healing in specific operations, such as plastic surgery, breast surgery, gastrointestinal surgery, and hip surgery. They found surgical site infection and wound delayed healing more frequently in smokers. But in a few small studies and some surgery, conflicting results were found. Besides, risk factors associated with wound complications include infection, smoking, aging, malnutrition, immobilization, diabetes, vascular disease, and immunosuppressive therapy. This study aims to determine the impact of smoking on wound complications for all kinds of major surgeries. To clarify the risks, our study uses the updated National Surgical Quality Improvement Program (NSQIP) database to find if patients who were active smokers are more likely to have wound-related complications postoperatively. We hypothesized that the active smoking population will have increased infectious complications and wound dehiscence compared with the nonsmoking population.


Recruitment information / eligibility

Status Completed
Enrollment 1150000
Est. completion date December 2, 2021
Est. primary completion date November 28, 2021
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - From NSQIP dataset, patients with complete information for baseline parameters and without preoperative open wound infections Exclusion Criteria: - Incomplete information of baseline parameters, and with preoperative wound infection

Study Design


Locations

Country Name City State
Taiwan Taipei Medical University Hospital Taipei

Sponsors (1)

Lead Sponsor Collaborator
Taipei Medical University Hospital

Country where clinical trial is conducted

Taiwan, 

Outcome

Type Measure Description Time frame Safety issue
Primary wound complications surgical site infection and wound disruption within 30 days after the primary procedure
Secondary pulmonary complications reintubation or ventilator > 48 hours within 30 days after the primary procedure
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