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Smoking Cessation clinical trials

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NCT ID: NCT05786547 Recruiting - Smoking Cessation Clinical Trials

V+PSF-M for Tobacco Cessation in HIV Care in India

Start date: January 2, 2024
Phase: Phase 3
Study type: Interventional

The goal of this research study is to test an intervention to help quit tobacco use in participants with Human Immunodeficiency Virus (HIV). The study interventions used in this research study are: - Positively Smoke Free - Mobile (PSF-M) (mobile behavioral program) - Varenicline (or Chantix, apovarenicline, Champix or Nocrav)

NCT ID: NCT05777005 Recruiting - Smoking Cessation Clinical Trials

Promoting Smoking Cessation in Campus

Start date: March 6, 2023
Phase: N/A
Study type: Interventional

This study aims to explore the feasibility, preliminary effectiveness, and implementation outcomes of chatbot-led smoking cessation support in community smokers.

NCT ID: NCT05764759 Recruiting - Smoking Cessation Clinical Trials

Investigating Novel Smoking Cessation Primary Care Interventions in Rural Environments

INSPIRE
Start date: March 7, 2023
Phase: N/A
Study type: Interventional

The purpose of this research study is to evaluate an electronic visit (e-visit) for smoking cessation across rural primary care settings. Participants will be randomly assigned to receive either the smoking cessation e-visit or not. The e-visit will look similar to an online questionnaire asking about smoking history, motivation to quit, and preferences for medications for quitting smoking. Participants may receive a prescription for a smoking cessation medication as an outcome of the e-visit, if randomized to the e-visit group, but there is no requirement to take any medication. This study consists of questionnaires and breath samples provided at 4 separate time points throughout the study. Participation in this study will take about 24 weeks.

NCT ID: NCT05746442 Recruiting - HIV Clinical Trials

Ending Tobacco Use Through Interactive Tailored Messaging for Cambodian People Living With HIV/AIDS

ProjectENDIT
Start date: January 11, 2023
Phase: N/A
Study type: Interventional

The goal of this research study is to test how well an automated text messaging smoking treatment program helps smokers with HIV quit smoking.

NCT ID: NCT05738408 Recruiting - Smoking Cessation Clinical Trials

Remote Smoking Cessation in Hospitalized Cardiac Patients

Start date: August 12, 2022
Phase: N/A
Study type: Interventional

The investigators are proposing to examine new strategies for helping patients hospitalized for an acute coronary event adhere to recommendations to quit smoking. The investigators are interested to see whether offering financial incentives for smoking cessation, combined with medications to ameliorate withdrawal, can significantly reduce smoking in a population for which continued smoking has disproportionately negative health effects. The proposed trial can provide significant knowledge for promoting adherence to smoking cessation guidelines in patients with cardiac disease

NCT ID: NCT05733767 Recruiting - Smoking Cessation Clinical Trials

Smoking Cessation Pharmacotherapy-Nurse Practitioner Led Tobacco Treatment Team Study

STOP-NPT3
Start date: November 3, 2022
Phase: Phase 2
Study type: Interventional

Tobacco use remains the leading cause of death in the United States and contributes to more than 7 million hospitalizations annually. Being admitted to the hospital offers the perfect opportunity to support smoking cessation. Patients are motivated to quit because of their current illness and societal guidelines recommend clinicians should counsel patients and prescribe smoking cessation pharmacotherapy (SCP) to virtually all smokers. However, only 22% of patients are prescribed SCP while hospitalized, and only 1% are prescribed medications compatible with current guidelines. This failure is part of the reason 70-80% of hospitalized smokers eventually relapse. The relapse typically occurs within a few days of hospital discharge - well before outpatient follow-up can occur. The investigators aim to improve smoking cessation treatment and guideline adherence by utilizing the opportunity that hospitalization provides. The investigators have created a tobacco treatment team (T3) to overcome physicians' and patients' low use of current guideline smoking cessation medications. The team members are trained in tobacco treatment and will be led by a nurse practitioner (NPT3). The team will work together and 1) prescribe individually tailored and guideline-concordant SCP; 2) counsel and motivate patients to use SCP properly; and 3) manage a mobile phone-based text-messaging system to keep patients motivated and adherent to SCP. Our preliminary data suggest that such an approach is workable and acceptable to patients, physicians, and hospital administrators. The investigators will recruit 424 patients in the hospital who smoke with cardiopulmonary disease. These patients will be randomized to receive either usual care or personalized care with the NPT3 team. The investigators will compare rates of guideline-concordant SCP use at 1 week and exhaled carbon monoxide (eCO) verified smoking cessation at 6 months between patients randomized to the NPT3 team vs. usual care. The investigators will also measure the project's economic value from a hospital and payer perspective. Understanding the economic value will better inform hospital and insurance policies and sustainability. Finally, acceptability, generalizability, and sustainability measures will be assessed through qualitative interviews with patients, providers, and hospital leadership.

NCT ID: NCT05732272 Recruiting - Smoking Cessation Clinical Trials

Improving Smoking Abstinence Outcomes in the African American Community Through Extended Treatment

(KISV)
Start date: February 28, 2023
Phase: Phase 3
Study type: Interventional

This study will evaluate the efficacy of extended bupropion(6 months) versus standard bupropion treatment (7 weeks) among African American daily smokers.

NCT ID: NCT05732220 Active, not recruiting - Smoking Cessation Clinical Trials

Mobile EMA-based Peer Counselling for Youth Smokers

Start date: May 18, 2023
Phase: N/A
Study type: Interventional

This pilot trial aims to examine the feasibility, acceptability, and preliminary effectiveness of EMA-based peer counseling for youth smokers.

NCT ID: NCT05729243 Recruiting - Smoking Cessation Clinical Trials

Cytisine for Smoking Cessation

Start date: February 8, 2023
Phase: Phase 4
Study type: Interventional

The goal of this clinical trial is to evaluate the safety and effectiveness of cytisine as a smoking cessation treatment in individuals with concurrent alcohol use disorder.

NCT ID: NCT05724810 Recruiting - Schizophrenia Clinical Trials

Deep rTMS Modulating Insula Synaptic Density and Smoking Behavior in Schizophrenia

Start date: April 4, 2023
Phase: N/A
Study type: Interventional

Purpose of the study: Evaluate the effect of deep repetitive transcranial magnetic stimulation (deep rTMS; hereafter abbreviated as "dTMS") on synaptic density measured with positron emission tomography (PET) and the radiotracer [11C]UCB-J. The investigators also seek to link plasticity changes in the regions targeted by the electric field (especially, the insula) to changes in the functioning of insula circuits and behavioral cigarette usage in patients with schizophrenia (SCZ). Importance of the study: This is the first study designed to directly evaluate the mechanism of action (MOA) of dTMS for smoking disruption in patients with SCZ. Patients with SCZ are a vulnerable population in high, immediate need of new smoking therapeutics for reducing premature morbidity and mortality.